A Space-Time Continuum for Immunotherapy Biomarkers in Gastroesophageal Cancer?

A Space-Time Continuum for Immunotherapy Biomarkers in Gastroesophageal Cancer?
Clin Cancer Res. 2020 Oct 06;:
Authors: Klempner SJ, Upadhyay V, Chao J
Abstract
In an annotated series of gastroesophageal adenocarcinomas differences in PD-L1 expression and TMB occur between both paired contemporaneous primary and metastatic biopsies and pre/post-treatment samples. This work has implications for optimizing patient selection, serial testing, need for mechanistic understanding, and may underlie variable responses to checkpoint inhibitors in gastroesophageal cancers.
PMID: 33023951 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - October 6, 2020 Category: Cancer & Oncology Authors: Klempner SJ, Upadhyay V, Chao J Tags: Clin Cancer Res Source Type: research