Interleukin-35 has a Tumor-promoting Role in Hepatocellular Carcinoma.

CONCLUSIONS: Elevated IL-35 had an immune suppressive role in HCC tumor microenvironments through affecting inhibitor receptor expression and cytokine secretion of CD4+ and CD8+ T cells. Dissection of the precise targets and underlying molecular mechanisms would mean alternative treatments for HCC patients. (250 words).
PMID: 33030251 [PubMed - as supplied by publisher]

Source: Clinical and Developmental Immunology - October 8, 2020 Category: Allergy & Immunology Authors: Liu X, Ren H, Guo H, Wang W, Zhao N Tags: Clin Exp Immunol Source Type: research