AAIC 2020: Unprecedented success in an unprecedented time.
AAIC 2020: Unprecedented success in an unprecedented time. Alzheimers Dement. 2020 Oct;16(10):1469-1473 Authors: PMID: 33027548 [PubMed - in process]
Blood vessels passing through the central nervous system are sheathed by specialized cells that form the blood-brain barrier. The barrier controls the passage of cells and molecules into the brain. This protection is essential to the normal function of the brain, which operates in a biological environment that is very different to that of the result of the body. Unfortunately, and like all systems in the body, the blood-brain barrier deteriorates with age. This allows harmful molecules and cells to leak into the brain, provoking a damaging state of chronic inflammation in brain tissue. Inflammation is thought to be an impo...
Hyperbaric oxygen therapy increased cerebral blood flow and improved cognition in a small study of older adults with memory problems.Medscape Medical News
This article is protected by copyright. All rights reserved
[SAnews.gov.za] Today marks World Alzheimer's Day, which is commemorated annually on 21 September.
CNS Neurol Disord Drug Targets. 2021 Sep 20. doi: 10.2174/1871527320666210920120612. Online ahead of print.ABSTRACTAlzheimer's disease is inflating worldwide and is combatted by only a few approved drugs. At best, these drugs treat symptomatic conditions by targeting cholinesterase and N-methyl-D-aspartate receptors. Most of the clinical trials in progress are focused to develop disease-modifying agents that aim single targets. The 'one drug-one target' approach is failing in the case of Alzheimer's disease due to its labyrinth etiopathogenesis. Traditional medicinal systems like ayurveda uses a holistic approach encompass...
Nature Reviews Neurology, Published online: 21 September 2021; doi:10.1038/s41582-021-00545-1To date, all phase III trials of β-site amyloid precursor protein (APP)-cleaving enzyme (BACE) inhibitors for Alzheimer disease were either discontinued or produced negative results. Here the authors present their opinion that BACE inhibitors still hold promise as a preventative therapy for Alzheimer disease and outline a series of experiments to inform future trials.
Molecular Psychiatry, Published online: 21 September 2021; doi:10.1038/s41380-021-01307-7Correction: APOE4-mediated Alzheimer disease and “Vascular”—“Meningeal Lymphatic” components: towards a novel therapeutic era?
In today's open access paper, researchers report a modest improvement in cerebral blood flow and cognitive performance in a small study of older individuals suffering cognitive impairment as a result of sustained hyperbaric oxygen treatment over a period of months. This seems a compensatory approach to therapy, in that improvements in cerebral blood flow should be expected to improve cognitive function at any age. This is the mechanism by which exercise rapidly improves memory function, for example. A direct comparison of hyperbaric oxygen treatment and exercise would be interesting. This result might help to inform...
This study presents, for the first time, an EFhd2 brain interactome that it is associated with different cellular and molecular processes.These findings will help prioritize further studies to investigate the mechanisms by which EFhd2 modulates these processes in physiological and pathological conditions of the nervous system.
This study indicates that genetically predicted elevated CRP levels may be a causal risk factor for AD.PMID:34538509 | DOI:10.1016/j.neurobiolaging.2021.08.010