Where Mitochondria Meet Autoimmunity: The Treg Cell Link.

Where Mitochondria Meet Autoimmunity: The Treg Cell Link.
Cell Metab. 2020 Oct 06;32(4):507-509
Authors: Procaccini C, Matarese G
Abstract
Although a crucial role for mitochondrial metabolism in controlling T regulatory (Treg) cell function has been recognized, its contribution during autoimmunity has not yet been fully elucidated. In this issue of Cell Metabolism, Alissafi and colleagues demonstrate that during autoimmunity, Treg cell functional alterations associate with mitochondrial oxidative stress, dysfunctional mitophagy, and enhanced DNA damage response, culminating with their cell death.
PMID: 33027671 [PubMed - in process]

Source: Cell Metabolism - October 6, 2020 Category: Cytology Authors: Procaccini C, Matarese G Tags: Cell Metab Source Type: research