ABHD15 promotes cell viability, glycolysis, and inhibits apoptosis in cardiomyocytes under hypoxia

Myocardial infarction (MI) has been an important heart disease affecting human health. The aim of this study was to investigate the regulatory effect of abhydrolase domain containing 15 (ABHD15) on hypoxic cardiomyocytes.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research

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Exposure to heavy metals is common. This exposure is related to environmental contamination of air, water and soil, occupational exposure, accumulation in food, tobacco, and other factors. Cadmium and lead are notable for their widespread contamination, long-lasting effects in the body, and renal as well as cardiovascular toxicity. Acute toxicity due to high-level exposure, as well as chronic low-level exposure are now well-established pathogenic entities. Both chronic renal failure and ischemic heart disease patients have been treated separately in recent studies with ethylenediaminetetraacetic acid (EDTA) chelation thera...
Source: Cardiology in Review - Category: Cardiology Tags: Invited Review Articles Source Type: research
Researchers here suggest that the processes of atherosclerosis, leading to the buildup of fatty deposits that narrow and weaken blood vessels, are cumulative over time. One of the risk factors is high blood cholesterol, and high cholesterol in youth is found to correlate with increased risk in later life, even if blood cholesterol has been restored to normal levels at that time. This is interesting, as the cause of atherosclerosis is less blood cholesterol per se and more the oxidized cholesterol that disrupts the function of macrophage cells responsible for cleaning up cholesterol in blood vessel walls. Those macrophages ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
HEART attack symptoms include difficulty breathing, chest pain, and an overwhelming feeling of anxiety. But you could also be at risk of a deadly myocardial infarction and heart disease symptoms if you develop a number of tell-tale signs that you may be missing. Should you consider speaking to a doctor?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusions The NovaCross met both the primary safety endpoint and the primary efficacy endpoint. We, therefore, conclude that the device is well tolerated, effective, and could be easily adopted by interventional cardiologists.
Source: Coronary Artery Disease - Category: Cardiology Tags: PCI Source Type: research
Many fields of medicine are undergoing a transformation due to the COVID-19 pandemic, as patients are kept away from clinics as much as possible. Patients are now regularly visited by their doctors over video calls, are asked to perform certain proce...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiology Exclusive Medicine Military Medicine Pediatrics Source Type: blogs
Having a spouse in a hospital intensive care unit increases a person's risk for a heart attack or cardiac-related hospitalization, according to a study published in the journal Circulation.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
(The Translational Genomics Research Institute) Avery Therapeutics Inc. of Tucson has developed an engineered heart tissue, a lab-grown cardiac membrane that can help heal the heart, either following a heart attack or as a result of progressive heart disease. The heart tissue, called MyCardia ™ , could revolutionize the treatment of cardiovascular disease, and someday might be applied to other failing organs. To better understand how MyCardia works -- at the infinitesimally small molecular level -- Avery has partnered with TGen.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Cardiologists are finding that problems aren ’t related to age or severity of infectionCoronavirus – latest updatesSee all our coronavirus coverageOn 29 February, Melissa Vanier, a 52-year-old postal worker from Vancouver, had just returned from holiday in Cuba when she fell seriously ill with Covid-19. “For the entire month of March I felt like I had broken glass in my throat,” she says, describing a range of symptoms that included fever, migraines, extreme fatigue, memory loss and brain fog. “I had to sleep on my stomach because otherwise it felt like someone was strangling me.”By the ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Science Medical research Heart attack Source Type: news
Conclusions: Our findings indicated a pivotal role of TBC1D15 in acute MI-induced cardiac anomalies through Fis1/RAB7 regulated mitochondria-lysosome contacts and subsequent lysosome-dependent mitophagy flux activation, which may provide a new target in the clinical treatment of acute MI.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
HEART disease could put an end to your life prematurely. The condition is heavily linked to a heart attack and stroke. Which seemingly harmless pastime could be contributing to this deadly outcome?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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