Insulin-like growth factor 1 promotes the extension of Tracheal Epithelium in an in Vitro Tracheal organ culture model

Rapid epithelialization is crucial to maintain tracheal patency and prevent potential graft failure in tracheal reconstruction after tracheal resection for cancer with tracheal infiltration or tracheal stenosis. Insulin-like growth factor 1 is a liver-secreted endocrine molecule that controls cell proliferation, differentiation, and apoptosis and has been reported to promote epithelialization in several organs. Here, we utilized mouse tracheal organ cultures to examine the effect of insulin-like growth factor 1 on tracheal epithelialization.

Source: Auris, Nasus, Larynx - October 8, 2020 Category: ENT & OMF Authors: Ippei Kishimoto, Hiroe Ohnishi, Kohei Yamahara, Takayuki Nakagawa, Masaru Yamashita, Koichi Omori, Norio Yamamoto Tags: Original Article Source Type: research