Maternal Obesity Affects the Glucose-Insulin Axis During the First Trimester of Human Pregnancy

Background and objective: The maternal glucose-insulin axis is central for metabolic adaptations required for a healthy pregnancy. Metabolic changes in obese mothers in early pregnancy have been scantly described. Here we characterized the glucose-insulin axis in the first trimester of human pregnancy and assessed the effect of maternal obesity and fat mass.Methods: In this cross-sectional study, maternal blood samples (N = 323) were collected during voluntary pregnancy termination (gestational age 4+0–11+6 weeks) after overnight fasting. Smokers (N = 198) were identified by self-report and serum cotinine levels (ELISA). Maternal BMI (kg/m2) and serum leptin (ELISA) were used as proxy measures of obesity and maternal fat mass, respectively. BMI was categorized into under-/normal weight (BMI
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

Related Links:

More News: Diabetes | Diabetes Mellitus | Eating Disorders & Weight Management | Endocrinology | Insulin | Obesity | PET Scan | Pregnancy | Smokers | Study