Maternal Obesity Affects the Glucose-Insulin Axis During the First Trimester of Human Pregnancy

Conclusions: At the group level, fasting glucose, C-peptide and insulin sensitivity dynamically change in the first trimester of human pregnancy. Maternal obesity is associated with higher C-peptide and lower insulin sensitivity at all periods in the first trimester of human pregnancy, while glucose is unaltered. These findings have implications for the timing of early gestational diabetes mellitus risk screening.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research