Cardiac morphological and functional changes induced by C-type natriuretic peptide are different in normotensive and spontaneously hypertensive rats

Conclusion: Chronic CNP treatment appears to attenuate hypertension and associated end-organ damage in the heart by reducing inflammation and fibrosis.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Experimental studies Source Type: research

Related Links:

Objectives: We aimed to determine if the ankle--brachial index (ABI) increased with age as a result of increased arterial stiffness and wave reflection, and whether this was associated with left ventricular hypertrophy (LVH). Methods: An observational cross-sectional study was conducted in 13 396 participants aged 19–89 years who attended a health check-up. Brachial and ankle blood pressures were measured by an automatic oscillometric method. Electrocardiography-determined LVH (ECG-LVH) was defined by computer-interpreted Minnesota codes using resting 12-leads ECG. Results: The mean age of the participants ...
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: BP measurement Source Type: research
AbstractPurposeLower aerobic fitness increases the risk of developing hypertension. Muscle sympathetic nerve activity (MSNA) is important for the beat-by-beat regulation of blood pressure. Whether the cardiovascular consequences of lower aerobic fitness are due to augmented transduction of MSNA into vascular responses is unclear. We tested the hypothesis that aerobic fitness is inversely related to peak increases in total peripheral resistance (TPR) and mean arterial pressure (MAP) in response to spontaneous MSNA bursts in young males.MethodsRelative peak oxygen consumption (VO2peak, indirect calorimetry) was assessed in 1...
Source: Clinical Autonomic Research - Category: Research Source Type: research
Authors: Ntchapda F, Bonabe C, Atsamo AD, Kemeta Azambou DR, Bekono Fouda Y, Imar Djibrine S, Seke Etet PF, Théophile D Abstract Background: Adansonia digitata is a plant used against cardiovascular disorders in African folk medicine. We assessed the effects of the aqueous extract of its stem bark on the development of hypertension in L-NAME-induced hypertensive rats. Methods: The animals were administered L-NAME once daily for 3 weeks (25 mg/kg, i.p.), concomitantly with aqueous extract of A. digitata stem bark (100 and 200 mg/kg, p.o.) or captopril (20 mg/kg, p.o.). Then, hemodynam...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
AbstractAimsA substantial shift in the field of pulmonary hypertension (PH) is ongoing, as the previous practice of mean pulmonary arterial wedge pressure (PAWPM) is no longer supported. Instead, aiming for a better estimate of end ‐diastolic pressures (EDP), instantaneous PAWP at mid‐A‐wave (PAWPmid ‐A) or, in the absence of an A ‐wave, at 130–160 ms following QRS onset has recently been recommended. Electrocardiogram‐gated PAWP (PAWPQRS) has also been proposed. The quantitative differences as well as the diagnostic and prognostic utility of these novel PAWP measurements have not been evaluated. We ...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
AbstractTo determine whether a beat-by-beat cardiovascular index (CARDEAN: cardiovascular depth of analgesia, Alpha-2 Ltd, Lyon, France) reduces the incidence of tachycardia in ASA I –III patients undergoing orthopaedic surgery. A total of 76 patients were prospectively randomized into (1) a control group or (2) the CARDEAN group, in which the nurse anaesthetist was blinded to CARDEAN application. In addition to conventional signs, an external observer instructed the nurse ana esthetist to administer sufentanil 0.1 µg kg−1 when the CARDEAN crossed a threshold ( ≥ 60). The primary outcome...
Source: Journal of Clinical Monitoring and Computing - Category: Information Technology Source Type: research
Harfiya Due to the growing public awareness of cardiovascular disease (CVD), blood pressure (BP) estimation models have been developed based on physiological parameters extracted from both electrocardiograms (ECGs) and photoplethysmograms (PPGs). Still, in order to enhance the usability as well as reduce the sensor cost, researchers endeavor to establish a generalized BP estimation model using only PPG signals. In this paper, we propose a deep neural network model capable of extracting 32 features exclusively from PPG signals for BP estimation. The effectiveness and accuracy of our proposed model was evaluated by the ...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Rationale: Paroxysmal autonomic instability with dystonia (PAID) is an underdiagnosed syndrome that describes a collection of symptoms following diverse cerebral insults, such as traumatic brain injury, hydrocephalus, hemorrhagic stroke, or brain anoxia. It is manifested by systemic high blood pressure, hyperthermia, tachycardia, tachypnea, diaphoresis, intermittent agitation, and certain forms of dystonia. Patient concerns: A semi-comatose 46-year-old man was transferred from the regional rehabilitation hospital with various complaints involving fluctuating vital signs, including uncontrolled hyperthermia, hypertensi...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
In this study,mitral valve closure (MVC) and isovolumetric contraction time (IVCT) wereassessed as valid markers for pulmonary artery pressure, compared againstintracardiac pressures measured simultaneously at the time of right heartcatheterization.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 245 Source Type: research
Atrial enlargement  The normal P wave has a maximum amplitude of 2.5 mm (0.25 mV) and a maximum width of 2.5 mm (100 ms). In right atrial enlargement, the amplitude increases while in left atrial enlargement, it is the width (duration) which increases. Both increases in biatrial enlargement. P wave abnormalities are best assessed in leads II and V1. Normal P wave is upright in lead II. In V1, a tiny initial spike is followed by a shallow negative wave. P mitrale: P mitrale is a notched and broad P wave with taller second peak indicating left atrial enlargement. It may be noted that initial part of P wave is contribut...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: HBC incomplete right bundle branch block pattern Left ventricular pressure overload left ventricular volume overload LVH strain pattern P mitrale P pulmonale P tricuspidale Right ventricular pressure overload right ventricular volume ove Source Type: blogs
CONCLUSION: Right ventricular pressure overload in APE has an effect on f(QRS-T). In thrombolytic treatment, the change of f(QRS-T) angle may be a marker of successful thrombolysis. PMID: 32975629 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
More News: Cardiology | Cardiovascular | Electrocardiogram | Heart | Hypertension | Study