Efficacy and safety-in analysis of short-course radiation followed by mFOLFOX-6 plus avelumab for locally advanced rectal adenocarcinoma

Neoadjuvant chemotherapy and short-course radiotherapy followed by resection has been gaining recognition in the treatment of rectal cancer. Avelumab is a fully human immunoglobulin that binds Programmed Death...
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research

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CONCLUSION: The study failed to meet the required 3 pCRs in the first 18 pts. The DFS in this population is encouraging and supports the hypothesis that select pts with rectal cancer may be spared from radiation. PMID: 32649004 [PubMed - as supplied by publisher]
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
CONCLUSION: Long-course radiotherapy with delay seems not to be different than short-course radiotherapy with delay, but prolongs substantially the treatment time. PMID: 32277614 [PubMed - as supplied by publisher]
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
CONCLUSIONS: Overall, while CRT did not impact genomic profiles, CRT impacted the tumor immune microenvironment, particularly in resistant cases. PMID: 31253631 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
This study had a retrospective multicenter (two hospitals in China) design and a radiomic analysis was performed using contrast enhanced CT in advanced HGSOC (FIGO stage III or IV) patients. We used a minimum 18-month follow-up period for all patients (median 38.8 months, range 18.8–81.8 months). All patients were divided into three cohorts according to the timing of their surgery and hospital stay: training cohort (TC) and internal validation cohort (IVC) were from one hospital, and independent external validation cohort (IEVC) was from another hospital. A total of 620 3-D radiomic features were extracted and a Lass...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsThis case highlights the occurrence of Fournier ’s gangrene as an extremely rare but life-threatening complication during neoadjuvant radiotherapy for rectal cancer which should be refreshed in the awareness of radiation oncologists and radiologists.
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
Introduction: Neoadjuvant CRT is the standard of care for clinical stage T3-4 or node positive rectal adenocarcinoma, but it is associated with a 12% rate of acute grade 3-4 diarrhea and 9% rate of longterm gastrointestinal (GI) toxicities1. Furthermore, the rate of complete pathologic responses to neoadjuvant therapy is low in historic studies (8%)1. Reducing GI toxicity is important because these side effects can lead to delayed or incomplete treatment, which may compromise patient outcomes. Novel agents which may improve pathologic response are of interest, as pCR is associated with improved local control and survival. ...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Abstract AimTo examine the overall survival differences of neoadjuvant therapy modalities: no therapy, chemotherapy alone, radiation alone, and chemoradiation in a large cohort of patients with locally advanced rectal cancer. MethodAdults with clinical stage II and III rectal adenocarcinoma were selected from the National Cancer Database and grouped by type of neoadjuvant therapies received: no therapy, chemotherapy only, radiotherapy only, or chemoradiation. Multivariable regression methods were used to compare adjusted differences in perioperative outcomes and overall survival. ResultsAmong 32978 patients included, 9714 ...
Source: Colorectal Disease - Category: Gastroenterology Authors: Tags: Original Article Source Type: research
Objective: To compare acute adverse events (AE) and postoperative complication rates in a randomized trial of short-course (SC) versus long-course (LC) preoperative radiotherapy. Background: Evidence demonstrates that adding neoadjuvant radiotherapy to surgery offers better local control in the management of rectal cancer. With both SC and LC therapy there is a potential for acute treatment-related toxicity and increased patient morbidity. Methods: Eligible patients had clinical-stage T3 rectal adenocarcinoma within 12 cm of the anal verge with no evidence of metastasis. SC consisted of pelvic radiotherapy 5 ×...
Source: Annals of Surgery - Category: Surgery Tags: Randomized Controlled Trials Source Type: research
Aims: To assess clinical and pathological outcomes in patients receiving neoadjuvant chemoradiation for locally advanced rectal adenocarcinoma.
Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
Abstract: To investigate the outcomes of the selective neoadjuvant concurrent chemoradiotherapy (CCRT) in lower 3rd rectal cancer patients in different groups (with or without neoadjuvant CCRT), especially in survival rate, local recurrence rate, and sphincter preservation rate. From January 1999 to December 2012, 69 consecutive patients who had histologically proven adenocarcinoma of lower 3rd rectum, defined preoperatively as lower tumor margin within 7 cm from the anal verge as measured by rigid sigmoidoscopy, received total mesorectum excision (TME). Our inclusion criteria of neoadjuvant CCRT are lower 3rd rectal ca...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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