Pain, sensitization and physical performances in patients with chronic painful knee osteoarthritis or chronic pain following total knee arthroplasty: An explorative study

ConclusionsSimilar profiles for pain intensity, signs of sensitization and conditioned pain modulation were observed. Patients with TKA seems to have impaired physical performances compared with the OA group, underlining the importance of targeting physical performances. Only the OA patients showed an association between sensitization (TS) and physical performance.SignificanceQuantitative pain profiling assessment was used to assess pain intensities and pain mechanisms. We observed associations between physical performances and temporal summation in the OA group underlining the importance of assessing motor functions and pain mechanisms in the same trial. We observed lower levels of physical performances in the TKA group compared with the OA group, suggesting that examination and rehabilitation of physical performances is essential for TKA patients with chronic pain.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: ORIGINAL MANUSCRIPT Source Type: research

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The majority of our knowledge of chronic pain in the general population comes from self-report studies. During the last three decades most of these population-based surveys have found that 20% to 35% of the general population suffer from chronic pain [4,6,10,22,23,25,27]. Globally, it is estimated that low back pain, migraine, neck pain, other musculoskeletal disorders, osteoarthritis, and tension type headache are rank numbered 1, 2, 6, 7, 12, and 28 with respect to causes of years lived with disability and that respectively 650, 850, 350, 250, 240, and 1560 million people worldwide suffer from these pain-related disorders [28].
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
AbstractN-of-1 trials are randomized controlled clinical trials conducted exclusively on a single patient. The ultimate aim of N-of-1 trials is to optimize a strategy in a particular individual. Chronic pain is a common but refractory clinical problem. Its diverse etiologies and broad variations among patients often lead to the requirement of individualizing medicine. Thus, chronic pain represents a classical condition for N-of-1 clinical trials. Studies have indicated that N-of-1 benefits patients with chronic pain, multiple comorbidities, and uncertain variations during therapies; however, this approach it is not yet ado...
Source: Pain and Therapy - Category: Anesthesiology Source Type: research
Pain Res Manag. 2021 Feb 20;2021:5554631. doi: 10.1155/2021/5554631. eCollection 2021.ABSTRACTPURPOSE: To retrospectively evaluate the effectiveness of intra-articular application of Sluijter-Teixera Poisson pulsed radiofrequency (STP PRF) in knee osteoarthritis symptomatic patients with chronic pain refractory to conservative therapies.MATERIALS AND METHODS: Institutional database research of two centers identified 39 cases of knee osteoarthritis patients treated with intra-articular STP PRF. Pain prior and one-week and one-, three-, six-, and twelve-month post-STP PRF was compared by means of a numeric visual scale (NVS)...
Source: Pain Research and Management - Category: Anesthesiology Authors: Source Type: research
IJERPH, Vol. 18, Pages 9655: Long-Term Sequelae of Frostbite—A Scoping Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph18189655 Authors: Ivo B. Regli Giacomo Strapazzon Marika Falla Rosmarie Oberhammer Hermann Brugger Frostbite is tissue damage caused by freezing temperatures and constitutes an important cause of morbidity in cold climate zones and high altitude. The direct effects of sub-zero temperatures lead to tissue freezing, electrolyte shifts and pH alterations, microvascular damage, and eventually to cell death. Upon rewarming, inflammatory reperfusi...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
This study will evaluate the efficacy and safety of Xianling Gubao capsule in the treatment of KOA. The results of this experiment will provide evidence support for Xianling Gubao capsule in the treatment of KOA. Trial registration: OSF Registration number: DOI 10.17605/OSF.IO/ERM9C
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
Eur J Med Chem. 2021 Aug 27;225:113804. doi: 10.1016/j.ejmech.2021.113804. Online ahead of print.ABSTRACTInflammation is a most complex pathological process that gives birth to different diseases. Different inflammatory mediators are released during an inflammation responsible for acute pain and chronic inflammatory diseases like cancer, asthma, rheumatoid arthritis, osteoarthritis, neurodegenerative diseases, metabolic and cardiovascular disorders. The arachidonic acid pathway, which results in the production of inflammatory mediators, provides several targets for anti-inflammatory intervention. The most popularly used me...
Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
Conclusion Osteoarthritis is now the single most common cause of disability, mobility limitations, and persistent pain in older adults—especially AA older adults. To our knowledge, this will be the first study to systematically phenotype MEP in an older racial minority population with knee osteoarthritis and will be relevant for reducing knee pain and improving function.
Source: Nursing Research - Category: Nursing Tags: BRIEF REPORTS Source Type: research
Osteoarthritis of the knee is one of the leading causes of disability and work limitations in the United States, resulting in significantly decreased work productivity and loss of work. The definitive treatment of choice for end-stage osteoarthritis is total knee arthroplasty. However, up to 34% of patients who undergo TKA experience chronic pain. Long-term pain continues to pose a significant burden and directly undermines the goal in treatment of patients with osteoarthritis, and persistent postoperative pain is a major concern to the orthopaedic community. Finding ways to reduce the number of patients experiencing persi...
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Special Focus: Practice Perspectives Source Type: research
AbstractMetalloproteinases were first identified as collagen cleaving enzymes and are now appreciated to play important roles in a wide variety of biological processes. The aberrant activity and dysregulation of the metalloproteinase family are linked to numerous diseases including cardiovascular and pulmonary diseases, chronic wounds, cancer, fibrosis and arthritis. Osteoarthritis (OA) is the most prevalent age-related joint disorder that causes pain and disability, but there are no disease-modifying drugs available. The hallmark of OA is loss of articular cartilage and elevated activities of matrix-degrading metalloprote...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
Conclusion: ANGF could relieve pain and improve function effectively and are superior to other traditional drugs recommended by guidelines. Although no significant difference in tolerability and safety between ANGFs and placebo was found, the rapid progression of original osteoarthritis which may be related to the use of ANGFs still needs special attention and furtherly verification by clinical trials.Systematic Review Registration: PROSPERO, identifier [CRD42021258033].
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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