Endosomal dysfunction in iPSC-derived neural cells from Parkinson ’s disease patients with VPS35 D620N

Mutations in the Vacuolar protein sorting 35 (VPS35) gene have been linked to familial Parkinson ’s disease (PD), PARK17. VPS35 is a key component of the retromer complex, which plays a central role in endosomal t...

Source: Molecular Brain - October 8, 2020 Category: Neuroscience Authors: Keiko Bono, Chikako Hara-Miyauchi, Shunsuke Sumi, Hisayoshi Oka, Yasuyuki Iguchi and Hirotaka James Okano Tags: Research Source Type: research