Comparative pharmacokinetics of the three echinocandins in ICU patients

ConclusionsAnidulafungin exposure in ICU patients was comparable with that reported in non-ICU patients and in healthy volunteers. Micafungin exposure was comparable to that of other patients but ∼30% lower than that in healthy volunteers, whereas caspofungin exposure was rather low (∼50% lower than in healthy volunteers). Larger interindividual variability (50%–60%) was recorded in ICU patients compared with other groups for all three echinocandins.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research