Relationship between serum bepridil concentration and corrected QT interval.

Relationship between serum bepridil concentration and corrected QT interval. Int J Clin Pharmacol Ther. 2020 Oct 06;: Authors: Matsui K, Mukai Y, Sakakura K, Wada K, Nakamura T, Kawabata A, Terakawa N, Hayakawa N, Kusano K, Hosomi K, Yokoyama S, Takada M Abstract OBJECTIVE: Bepridil prolongs the QT interval and can induce torsade de pointes. Although increased bepridil concentration may be a primary cause of prolonged QT, the relationship between serum bepridil concentration and prolonged QT remains unclear. We investigated the relationship between serum bepridil concentration and the corrected QT (QTc) interval in patients treated with bepridil. MATERIALS AND METHODS: A retrospective study was performed at the National Cerebral and Cardiovascular Center in Japan. Patients with atrial fibrillation who were treated with bepridil from January 2014 to December 2015 were enrolled in the study. Serum bepridil concentrations and electrocardiogram data collected more than 21 days after the initiation of bepridil were used for analysis. RESULTS: A total of 60 patients were included in this study. There was a significant difference in mean QTc interval before and after initiation of bepridil (p 
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

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 This ECG was texted to me with the question" Wellens'? "The computer read was: Atrial Fibrillation, marked ST Elevation. ***Acute MI***The QT interval is short (377 ms, QTc = 399 ms)This is NOT atrial fibrillation: There is sinus arrhythmia with an accelerated junctional rhythm that competes with the sinus node and results in some AV dissociation (no AV block!).  This is completely benign.I responded: This STE with T-wave inversion looks like a normal variant for an African American.  I would check the troponin, but I do not think it is pathologic.Here is the history: The patient wa...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
To investigate if preoperative electrocardiogram scores and perioperative surgical methods could predict new-onset atrial fibrillation during lung surgery.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
Conclusions: IAB is associated with new-onset AF and death in CRT recipients and may be helpful in the risk stratification in the context of heart failure management. Abnormal PTFV1 did not demonstrate any prognostic value.Cardiology
Source: Cardiology - Category: Cardiology Source Type: research
ConclusionsConduction, rhythm, and electrocardiographic abnormalities were common during COVID ‐19 related hospitalization. Arrhythmic death was associated with age, coronary artery disease, asthma, longer admission corrected QT interval, LBBB, ventricular ectopy, and usage of vasopressors. Most died receiving comfort measures.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLES Source Type: research
AbstractAimsA substantial shift in the field of pulmonary hypertension (PH) is ongoing, as the previous practice of mean pulmonary arterial wedge pressure (PAWPM) is no longer supported. Instead, aiming for a better estimate of end ‐diastolic pressures (EDP), instantaneous PAWP at mid‐A‐wave (PAWPmid ‐A) or, in the absence of an A ‐wave, at 130–160 ms following QRS onset has recently been recommended. Electrocardiogram‐gated PAWP (PAWPQRS) has also been proposed. The quantitative differences as well as the diagnostic and prognostic utility of these novel PAWP measurements have not been evaluated. We ...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
AbstractIntroductionThe impact of atrial arrhythmias on COVID ‐19‐associated outcomes are unclear. We sought to identify prevalence, risk factors and outcomes associated with atrial arrhythmias among patients hospitalized with COVID‐19.MethodsAn observational cohort study of 1053 patients with SARS ‐CoV2 infection admitted to a quaternary care hospital and a community hospital was conducted. Data from electrocardiographic and telemetry were collected to identify atrial fibrillation (AF) or atrial flutter/tachycardia (AFL). The association between atrial arrhythmias and 30‐day mortality was assessed with multivari...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLES Source Type: research
Publication date: Available online 3 October 2020Source: Revista Portuguesa de Cardiologia (English Edition)Author(s): Daniel Bonhorst
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
Authors: Aono Y, Hamatani Y, Katoh N, Nakagawa M, Nakamura K, Yazaki M, Kametani F, Iguchi M, Murakami I, Ogawa H, Abe M, Akao M, Sekijima Y Abstract The patient was an 82-year-old Japanese man with no family history suggestive of amyloidosis. He developed bilateral leg edema and shortness of breath and was referred to our hospital. An electrocardiogram showed atrial fibrillation with right bundle branch block. Echocardiography showed concentric LV hypertrophy. An endomyocardial biopsy showed severe ATTR amyloid deposits. A genetic analysis of the transthyretin (TTR) gene revealed a heterozygous c.187C>T missens...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
ConclusionThe PIVoTAL is a prospective, randomized controlled trial designed to evaluate the outcomes of PVI alone versus PVI+PWI using the cryoballoon, in patients with symptomatic persAF. We hypothesize that PVI+PWI will prove to be superior to PVI alone for prevention of AF recurrence.
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
CONCLUSIONS: Patients on HCT therapy showed no difference in short term recurrence of AF after ablation compared to propensity matched controls. PMID: 32989962 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
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