IJERPH, Vol. 17, Pages 7343: Legionnaires ’ Disease on the Rise in Switzerland: A Denominator-Based Analysis of National Diagnostic Data, 2007–2016

This study aims to investigate this increase, contextualizing disease surveillance data with denominator data, which is not routinely available, i.e., the number of tests performed for Legionella spp. We collected the testing data for Legionella spp. of 14 Swiss diagnostic laboratories and calculated the positivity, defined as the proportion of the number of positive tests to the number of tests performed. The number of positive tests increased proportionally to the number of tests performed; hence, the positivity remained stable. However, the cause of the increase in test volume is unclear and has a large impact on the interpretation of the positivity curve. Further, the test outcome was found to be dependent on regional determinants, and the diagnostic method applied. The lack of understanding if and at which stage LD is considered in current case management of pneumonia patients limits the interpretation of observed heterogeneities in incidence or underestimation of LD in Switzerland. The absence of (or non-adherence to) existing guidelines and the heterogeneity in diagnostic testing hampers the comparison of data in the Swiss public health context. Therefore, diagnostic procedures should be harmonised across Switzerland and adherence to national LD management guidelines supported.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research

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Legionella pneumophila is an opportunistic pathogen that causes the potentially fatal pneumonia known as Legionnaires' Disease. The pathology associated with infection depends on bacterial delivery of effector proteins into the host via the membrane spanning Dot/Icm type IV secretion system (T4SS). We have determined sub-3.0 Å resolution maps of the Dot/Icm T4SS core complex by single particle cryo-EM. The high-resolution structural analysis has allowed us to identify proteins encoded outside the Dot/Icm genetic locus that contribute to the core T4SS structure. We can also now define two distinct areas of symmetry mi...
Source: eLife - Category: Biomedical Science Tags: Microbiology and Infectious Disease Source Type: research
In conclusion, this study has provided additional susceptibility data for environmental Legionella pneumophila isolates from Northern Italy demonstrating, in general, low MICs values for the tested antimicrobials, although one strain tested was shown to possess the LpeAB resistance determinant, indicating that future surveillance studies are warranted.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
We describe a March 2020 co-occurrence of Legionnaires' disease (LD) and coronavirus disease in France. Severe acute respiratory syndrome coronavirus 2 co-infections were identified in 7 of 49 patients from LD case notifications. Most were elderly men with underlying conditions who had contracted severe pneumonia, illustrating the relevance of co-infection screening.PMID:34469708 | DOI:10.3201/eid2711.202150
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Legionella pneumophila is an important pathogen and is involved in more than 95% of cases of severe atypical pneumonia. The current study focused on the ablution water in the grand mosque in Makkah as well as water tanks in hotels surrounding the holy mosque. A total of 100 water samples were collected from ablution water in the Haram and the hotels in the central area around the grand mosqu...
Source: African Journal of Microbiology Research - Category: Microbiology Source Type: research
Tidsskr Nor Laegeforen. 2021 Jun 28;141(11). doi: 10.4045/tidsskr.21.0092. Print 2021 Aug 17.ABSTRACTBACKGROUND: Most cases of legionellosis in Norway are acquired outside the country. This was a domestic case from an unusual source.CASE PRESENTATION: A man in his thirties was admitted with pneumonia early in the summer. He developed respiratory failure before recovering. Cultures from his lower airways grew Legionella pneumophila serogroup 1. Samples from his home and workplace did not identify Legionella. On further questioning it was discovered that the patient regularly sat beside an outdoor fountain during his breaks ...
Source: Tidsskrift for den Norske Laegeforening - Category: General Medicine Authors: Source Type: research
CONCLUSIONS: The patient had a favorable outcome with early diagnosis and early treatment of both diseases. Patients with severe COVID-19 disease need to be evaluated for co-infection. Further, early diagnosis and early treatment of the microbial bacteria causing the co-infection are important.PMID:34409491 | DOI:10.1186/s40981-021-00467-3
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Source Type: research
This study aimed to evaluate its ecology and to identify this Legionella species as a respiratory pathogen. A PCR assay for detecting the L. feeleii mip gene was developed to identify it in clinical and environmental samples. Culture and PCR were performed in environmental samples from four drinking water treatment plants (DWTPs). Free L. feeleii was only detected in raw water samples (3.4%), while L. feeleii as an Acanthamoeba endosymbiont was found in 30.7% of raw water, 11.5% of decanter biofilm, and 32% of finished water samples. Therefore, Acanthamoeba spp. plays an essential role in the multiplication, persistence, a...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
We report a case of the orange-coloured sputum and bronchoalveolar lavage fluid and the detailed medical interview about recent gardening activity and exposure to compost or potting mix, which might be signs for rapid diagnosis of non-pneumophilaLegionella species pneumonia with a negative urinary antigen test. AbstractWe herein report an immunocompromised patient familiar with gardening admitted to our hospital suffering from severe pneumonia caused byLegionella longbeachae. We suspected non-pneumophilaLegionella species pneumonia because of gardening habits, the negative urine antigen test and the non-significant Gram st...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: CASE REPORT Source Type: research
AbstractLefamulin  (Xenleta) has been approved by the US FDA for the treatment of community-acquired bacterial pneumonia (CABP). It may be taken intravenously or orally and has activity against a broad range of pulmonary pathogens, includingStreptococcus pneumoniae, Haemophilus influenzae,Mycoplasma pneumoniae,Legionella pneumophila, andChlamydophila pneumonia, as well as methicillin-resistantStaphylococcus aureus and vancomycin-resistantEnterococcus faecium. Lefamulin has an adverse effect profile that is similar to other antimicrobial agents commonly used to treat CABP. Despite these promising features, the use...
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
Environ Res. 2021 Jul 9:111649. doi: 10.1016/j.envres.2021.111649. Online ahead of print.ABSTRACTLegionellosis is a severe pneumonia caused by the inhalation of aerosols containing Legionella, Gram-negative bacteria present in the water systems of touristic-recreational facilities. The purpose of this study was to develop a scoring tool to predict the risk of both environmental contamination and Legionnaires' disease cases in such facilities in the Apulia region of southern Italy. We analyzed 47 structural and management parameters/risk factors related to the buildings, water systems, and air conditioning at the facilities...
Source: Environmental Research - Category: Environmental Health Authors: Source Type: research
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