Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache

We report multiple phenotypes with genetic correlation (P 
Source: International Journal of Epidemiology - Category: Epidemiology Source Type: research

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Publication date: Available online 30 September 2020Source: Journal of Hazardous MaterialsAuthor(s): Anthony Beauvois, Delphine Vantelon, Jacques Jestin, Martine Bouhnik-Le Coz, Charlotte Catrouillet, Valérie Briois, Thomas Bizien, Mélanie Davranche
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
CONCLUSION: The proposed PHARMAC criteria will give access to these important drugs to those people with T2DM who will likely benefit the most. PMID: 33032305 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Authors: Siamashvili M, Davis S Abstract INTRODUCTION: Bromocriptine mesylate quick release (QR) is a dopamine D2 receptor agonist and is the only oral, primarily centrally acting drug that can be used for the treatment of adults with type 2 diabetes. AREAS COVERED: The authors describe current recommendations on the use of bromocriptine mesylate QR. Major efficacy and safety parameters of the late phase trials, including The Cycloset Safety Trial, have been identified and presented. EXPERT OPINION: Efficacy of bromocriptine mesylate QR monotherapy appears to be low but is compensated by favorable safety pr...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Authors: Saavedra J, Reyes JG, Salinas DG Abstract Cytosolic Ca2+ concentration ([Ca2+ ]) has an important role in spermatozoa and hence it regulates fertilization. In male germinal cells, there are indirect evidences that this ion could regulate physiological processes in spermatogenesis. Since little is known about Ca 2+ homeostasis in spermatogenic cells, in this work we propose a mathematical model that accounts for experimental [Ca2+ ] dynamics triggered by blockade of the SERCA transport ATPase with thapsigargin in round rat spermatids, without external Ca2+ and with different extracellular lactate concentrat...
Source: Channels - Category: Molecular Biology Tags: Channels (Austin) Source Type: research
Publication date: December 2020Source: Journal of Functional Foods, Volume 75Author(s): Tingting Wang, Lin Zheng, Tiantian Zhao, Qi Zhang, Zhitong Liu, Xiaoling Liu, Mouming Zhao
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 9 October 2020Source: Neurología (English Edition)Author(s): N. Morollón, R. Belvís, A. De Dios, N. Pagès, C. González-Oria, G. Latorre, S. Santos-Lasaosa
Source: Neurologia - Category: Neurology Source Type: research
TYPE 2 diabetes may feel like a minefield - can you eat this or that without spiking blood sugar levels? If you're feeling peckish, what's a good, healthy option for lunch?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
One of the reasons why the Wheat Belly lifestyle is so spectacularly effective for restoring health, losing weight, and turning back the clock a decade or two is because we reject the flawed logic of conventional nutritional advice. There is a long list of reasons why conventional nutritional advice gets it so wrong, from logical blunders, to relying on flawed observational evidence (rather than clinical trials), to getting too cozy with Big Food companies like Coca Cola and Kraft. Let’s discuss a common and widely-held blunder in logic that is applied over and over again in nutrition: If something bad is replaced by...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates gluten-free grain-free grains undoctored wheat belly Source Type: blogs
Just because something bad is reduced or eliminated in cigarettes, it should not logically follow that cigarettes must now be good, right? Low-tar, filtered cigarettes may be less harmful than full-tar, unfiltered cigarettes, but still contain heavy metals like mercury, lead, and cadmium, as well as nicotine, naphthalene, arsenic, formaldehyde, ammonia and other toxic compounds. Low- or no-tar does NOT mean healthy. This may seem obvious, but it is surprising how many people—physicians and dietitians included—fall for such flawed logic when applied to nutrition. We saw this play out in yet another flawed analys...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle barley corn epidemiological gluten longevity rye white flour whole grains Source Type: blogs
I posed this question recently: Given the extravagant health successes people are experiencing by living the Wheat Belly lifestyle, are we on the dawn of an age of self-direction in health? If doctors misdiagnose/misclassify our acid reflux, irritable bowel syndrome, intractable constipation, migraine headaches, chronic sinusitis, asthma, depression, binge eating disorder, type 2 diabetes, rheumatoid arthritis, ulcerative colitis, autoimmune hepatitis, and hundreds of other conditions, which we then reverse on our own with the lifestyle changes we introduce . . . who needs the doctors? Christine provided her perspective: &...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Success Stories gluten grains microbiome nutrients self-directed health undoctored Source Type: blogs
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