Sexual and reproductive health in cystic fibrosis

Purpose of review With improving life expectancy and quality of life, sexual and reproductive health (SRH) has become an increasingly important aspect of patient-centered cystic fibrosis care. This review aims to describe advances in cystic fibrosis-related SRH and highlight optimal practices. Recent findings Recent publications suggest that people with cystic fibrosis follow a similar trajectory of sexual development and activity as their noncystic fibrosis peers, although contraception use is lower. Although fertility is reduced in patients with cystic fibrosis, improved survival and assisted reproductive technologies have led to an increasing pursuit and incidence of pregnancy. Cystic fibrosis transmembrane regulator modulators that correct the underlying cystic fibrosis defect might improve fertility and thus far appear safe in pregnancy, though data are limited. Despite medical knowledge of SRH in cystic fibrosis, patients continue to report they lack sufficient education about these aspects of their healthcare, and cystic fibrosis multidisciplinary teams are ill prepared to counsel their patients. Summary Understanding of the effects of cystic fibrosis on SRH continues to improve, although many questions remain regarding optimal care from the choice of contraception to the safety of cystic fibrosis-specific medications in pregnancy. Further development of cystic fibrosis-informed interdisciplinary specialist networks and a wider framework of practice would both...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: CYSTIC FIBROSIS: Edited by Peter J. Barry and Barry J. Plant Source Type: research

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Source: Postgraduate Obstetrics and Gynecology - Category: OBGYN Tags: Article Source Type: research
Over the past decades advances in Cystic fibrosis (CF) patient care have led to an improvement in patient survival, with the majority of patients reaching adulthood [1]. This improvement was accompanied by an increase in the quality of life [2]. One result of these changes in longevity, and quality of life, has been the female patients' ability to become parents, and for women to carry a pregnancy, and even multiple pregnancies to term [3].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
Chronic oral azithromycin therapy improves clinical outcomes in people with cystic fibrosis (CF) [1], and is recommended for treatment of CF lung disease [2]. Azithromycin is categorized as pregnancy class B; no evidence of impaired fertility or fetal harm was observed in mice and rats at maternally toxic doses [3]. However, no adequate/well-controlled studies are likely to be performed in pregnant women.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
CONCLUSIONS: Pregnancy outcomes are generally good in women with cystic fibrosis. Successful pregnancy is possible even in those women with FEV1
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
AbstractObjectivesSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) may trigger severe pneumonia in coronavirus disease of 2019 (COVID-19) patients through release of damage-associated molecular patterns (DAMPs) and recruitment of neutrophils in the lungs. Activated neutrophils induce inflammation and severe alveolar injury by releasing neutrophil extracellular traps (NETs). The backbones of many DAMPs and NETs are made of extracellular, cell-free DNA decorated with highly toxic compounds such as elastase, myeloperoxidase and citrullinated histones. Dornase alfa is a FDA-approved recombinant human DNAse 1 for th...
Source: Trials - Category: Research Source Type: clinical trials
This study is not a warning of a scary new epidemic of problems arriving with next year’s babies. Instead, it’s a peak behind the curtain at what might be the hidden story behind the marvelous kids we already see on today’s playgrounds across the country. Most are very healthy – among the healthiest kids in history. Yes, too many are overweight. Too many have asthma. Too many have allergies. Too many have learning problems. Too many start puberty early. More than half have some chronic illness. But this isn’t slowing kids down as much as the devastating infectious diseases of the past. It is a...
Source: Conversations with Dr Greene - Category: Child Development Authors: Tags: Uncategorized Source Type: blogs
The government must do more to protect key workers threatened with dismissal or put on unpaid leave if they’re off work self-isolating because of vulnerable relatives, says UNISON today (Wednesday). Anxious staff have come to UNISON with heartbreaking stories, terrified that if forced to go into work, they might take the virus home – with potentially devastating consequences. Local government and NHS employers have put agreements in place to protect the income of any staff off work because of the health of family members. But some employers – including councils and schools – are instead using Public...
Source: UNISON Health care news - Category: UK Health Authors: Tags: News Press release coronavirus dave prentis sick pay Source Type: news
BillionToOne wants to expand its diagnostic offerings and its most recent financing could give it a push in that direction. The Menlo Park, CA-based company has raised $15 million in a follow-on to its series A round. With this financing, the company BillionToOne has brought in more than $32.5 million. The private company noted previous investors, Hummingbird Ventures and NeoTribe Ventures led the investment round with participation from Y Combinator, Libertus Capital, Pacific 8 Ventures, Civilization Ventures, 500 Startups Istanbul, and HOF Capital. BillionToOne said it will use the proceeds to support the commercial expa...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Business Source Type: news
As their long-term prognosis improves, women with CF are increasingly choosing to have children, but the safety of CFTR modulators in pregnancy and breastfeeding is currently unknown.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
To examine contraceptive use, pregnancy intention and the association of hormonal contraceptive type with adverse health outcomes among women with cystic fibrosis (CF).
Source: Contraception - Category: OBGYN Authors: Tags: Original Research Article Source Type: research
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