Association Between Genetic Variant Scores and P2Y12 Inhibitor Effects

Conditions:   Stent Thrombosis;   Ischemic Stroke;   Recurrent Myocardial Infarction Intervention:   Sponsors:   Cipherome, Inc.;   Seoul National University Bundang Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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AbstractPurpose of reviewAtrial fibrillation is the commonest sustained arrhythmia in rheumatic heart disease and is associated with significant morbidity and mortality. In this review, we discuss its epidemiology, natural course and management with special emphasis on recent developments in understanding and treatment of atrial fibrillation in rheumatic heart disease.Recent findingsUse of direct oral anticoagulants appears promising, especially in developing countries where regular coagulation monitoring is a challenge. Also, restoration and maintenance of sinus rhythm in rheumatic atrial fibrillation appear feasible and ...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
AbstractAntiplatelet agents may increase the risk of infections via suppressing platelet-mediated immune response. Here we assessed the contribution of clopidogrel versus aspirin to the development of pneumonia during an acute ischemic stroke admission. A retrospective cohort study was conducted of acute ischemic stroke patients who were admitted to our hospital from 2015 to 2018. Included patients received uninterrupted clopidogrel or aspirin therapy and did not take other antiplatelet agents throughout their stay. The interest outcome was development of pneumonia after stroke. Conditional logistic regression model after ...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
Conditions:   Stent Thrombosis;   Ischemic Stroke;   Recurrent Myocardial Infarction Intervention:   Sponsors:   Cipherome, Inc.;   Seoul National University Bundang Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Stroke (CVA) or TIA;   Headache, Migraine;   Botulinum Toxins, Type A;   Cerebral Venous Sinus Thrombosis;   Carotid Dissection Artery;   Vertebral Dissection Artery;   Hemorrhagic Stroke;   Reversible Cerebral Vasoconstriction Syndrome Interventions:   Drug: Botox 200 UNT Injection;   Combination Product: Non Botox based Standard of Care Treatments for Headache/Migraine Sponsor:   University of Alberta Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Stroke (CVA) or TIA;   Headache, Migraine;   Botulinum Toxins, Type A;   Cerebral Venous Sinus Thrombosis;   Carotid Dissection Artery;   Vertebral Dissection Artery;   Hemorrhagic Stroke;   Reversible Cerebral Vasoconstriction Syndrome Interventions:   Drug: Botox 200 UNT Injection;   Combination Product: Non Botox based Standard of Care Treatments for Headache/Migraine Sponsor:   University of Alberta Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: A substantial portion of hospitalized AF patients did not receive any AC therapy, particularly those patients with an AF diagnosis in the second position on hospital records. The predictors of inpatient AC treatment that were identified may be helpful in the clinical decision-making process for patients who are hospitalized with AF. PMID: 33021129 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
CONCLUSIONS: Endogenous THBD acts as a protective factor in the brain during ischemic stroke and enhances vessel diameter and proliferation. These previously unknown properties of THBD could offer new opportunities to affect vessel function after ischemia and thereby improve stroke outcome. PMID: 33028093 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
Publication date: March 2021Source: Interdisciplinary Neurosurgery, Volume 23Author(s): Aimen Vanood, Sunitha Santhakumar, Ahmad Said
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Our case underlines the tight management of antithrombotic therapy in the context of acutely decompensated chronic kidney disease, ischemic stroke, and SARS ‐CoV2 infection, the development of stroke as a SARS‐CoV2 complication increase the chances of adverse outcomes that may be mitigated by a rapid recognition and institution of available treatments. AbstractOur case underlines the tight management of antithrombotic therapy in the context of acutely decompensated chronic kidney disease, ischemic stroke, and SARS ‐CoV2 infection, the development of stroke as a SARS‐CoV2 complication increase the chances of adverse...
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
AbstractObjectivesEvidences from either small series or spontaneous reporting are accumulating that SARS-CoV-2 involves the Nervous Systems. The aim of this study is to provide an extensive overview on the major neurological complications in a large cohort of COVID-19 patients.MethodsRetrospective, observational analysis on all COVID-19 patients admitted from February 23rd to April 30th, 2020 to ASST Papa Giovanni XXIII, Bergamo, Italy for whom a neurological consultation/neurophysiological assessment/neuroradiologic investigation was requested. Each identified neurologic complication was then classified into main neurolog...
Source: Journal of Neurology - Category: Neurology Source Type: research
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