U.S. FDA grants Fast Track designation to empagliflozin for the treatment of chronic kidney disease
Source: Boehringer Ingelheim Corporate News - Category: Research Source Type: news

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Conclusions: Patients with post-bulbar ulcers have a poorer prognosis than those with bulbar ulcers. After the diagnosis of hemorrhagic post-bulbar duodenal ulcer, close follow-up is necessary.Digestion
Source: Digestion - Category: Gastroenterology Source Type: research
Int J Dev Biol. 2021;65(7-8-9):475-485. doi: 10.1387/ijdb.210041rs.ABSTRACTKidney-related disorders affect millions of people worldwide. A survey of chronic kidney disease (CKD) patients showed that the burden of kidney diseases is increasing every year. The global burden of disease (GBD) study 2017 ranked CKD as the 12th leading cause of deaths worldwide. Hence, identification of the causes of kidney diseases, development of accurate diagnostic methods and novel therapeutics is highly relevant. Model organisms that faithfully recapitulate human diseases play important roles in understanding the disease process and provide...
Source: International Journal of Developmental Biology - Category: Biology Authors: Source Type: research
Source: International Journal of General Medicine - Category: General Medicine Tags: International Journal of General Medicine Source Type: research
This case series examines the usability of autogenous arteriovenous fistulas for hemodialysis in patients with chronic kidney disease and kidney failure.
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
Uirusu. 2020;70(2):175-184. doi: 10.2222/jsv.70.175.ABSTRACTChronic kidney disease of unknown etiology (CKDu) has emerged in endemic areas of Sri Lanka since the 1990s. The disease is a chronic but fatal disease. Until now, heavy metals and agrochemicals have been suspected as the cause of CKDu, but it has been still unknown. Recently, we have found a high seroprevalence to hantavirus in CKDu patients and reported that hantavirus infection is a risk of CKDu. Hantaviruses are rodent-borne zoonotic viruses. Here, I would like to introduce a story of the research from sero-epidemiology to the search for host animals.PMID:3454...
Source: Uirusu. Journal of Virology - Category: Virology Authors: Source Type: research
Clin Exp Pharmacol Physiol. 2021 Sep 20. doi: 10.1111/1440-1681.13545. Online ahead of print.ABSTRACTRenal functional reserve (RFR) reflects the ability of the kidney to enhance glomerular filtration rate (GFR) in response to a protein load. Chronic kidney disease (CKD) leads to diminished RFR, since the capacity for whole-body GFR to increase through hyperfiltration of remaining nephrons is limited. Evaluating 41,456 inpatients following computerised tomography we reported many exhibiting acute kidney injury (AKI) but more patients with recovering kidney function (AKR), presumably reflecting resolution of their critical c...
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Source Type: research
Chronic kidney disease, cardiovascular disease, and cognitive dysfunction are common in the elder population. There is evidence of a connection between these conditions, possibly by a shared vascular pathogene...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research Source Type: research
This pre-specified analysis of DAPA-CKD assessed the impact of sodium-glucose cotransporter 2 inhibition on abrupt declines in kidney function in high risk patients based on having chronic kidney disease (CKD) and severe albuminuria. DAPA-CKD was a randomized, double-blind, placebo-controlled trial had a median follow-up of 2.4 years. Adults with CKD (urinary albumin-to-creatinine ratio 200 –5000 mg/g and estimated glomerular filtration rate 25–75 mL/min/1.73m2) were randomized to dapagliflozin 10 mg/day matched to placebo (2152 individuals each).
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: clinical trial Source Type: research
ConclusionsThe observed pharmacokinetics and pharmacodynamics were similar to reported data for non-Japanese healthy subjects, which support further evaluation of AZD5718 at similar doses/exposures in Japanese and non-Japanese subjects for future evaluation in patients with CAD and CKD.
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research
ConclusionsHypocitraturia is not specific of ADPKD but it is also present in all tested nephropathies and is related with renal impairment and not with serum bicarbonate. It could be interesting to study urinary citrate as a marker of renal function and as a prognostic factor.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
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