Fda-crl-t1d

US FDA issues complete response letter for empagliflozin 2.5 mg as adjunct to insulin for adults with type 1 diabetes
Source: Boehringer Ingelheim Corporate News - Category: Research Source Type: news

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Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Title: Doctors Often Miss Signs of Type 1 Diabetes in KidsCategory: Health NewsCreated: 9/21/2021 12:00:00 AMLast Editorial Review: 9/21/2021 12:00:00 AM
Source: MedicineNet Diabetes General - Category: Endocrinology Source Type: news
Pancreatic beta cell failure is the hallmark of type 1 diabetes (T1D). Recent studies have suggested that pathogen recognizing receptors (PRRs) are involved in the survival, proliferation and function of pancreatic beta cells. So far, little is known about the role of alpha-protein kinase 1 (ALPK1), a newly identified cytosolic PRR specific for ADP-β-D-manno-heptose (ADP-heptose), in beta cell survival. In current study we aimed to fill the knowledge gap by investigating the role of Alpk1 in the apoptosis of MIN6 cells, a murine pancreatic beta cell line. We found that the expression of Alpk1 was significantly elevate...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study explores the disease experience of adolescents and young adults with T1DM focusing on the barriers and facilitators that characterise their disease self-care. Self-care requires complex decision making and cooperation between patients, their families, the healthcare team, and the social support system. Personal and social factors affect self-care, and specific challenges impact adolescents and young adults, putting them at a higher risk of poor glycaemic control and more severe complications.
Source: Journal of Pediatric Nursing - Category: Nursing Authors: Source Type: research
Describe the main themes present in Type 1 Diabetes nutrition related Instagram posts.
Source: Journal of the American Dietetic Association - Category: Nutrition Authors: Tags: Late-breaking Research Abstracts Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
CONCLUSIONS: This is the first article evaluating Pd and Tp-e parameters of children with DKA. In this study, cardiac arrhythmia risk markers were detected to be increased in children with DKA. Therefore, clinicians should be careful about the possibility of development of new arrhythmias during DKA treatment.PMID:34538047 | DOI:10.4274/jcrpe.galenos.2021.2021.0165
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Authors: Source Type: research
J Clin Res Pediatr Endocrinol. 2021 Aug 18. doi: 10.4274/jcrpe.galenos.2021.2021.0139. Online ahead of print.ABSTRACTIt is well-known that in children with type 1 diabetes (T1D), the frequency of celiac disease (CD) is increased due to unclear mechanisms including autoimmune injury as well as shared genetic predisposition. Although histopathologic examination is gold standard, avoiding unnecessary endoscopy is crucial. Therefore, from the perspective of the clinicians and patients' families, the diagnosis of celiac disease remains challenging. With these in mind, a joint working group (Type 1 Diabetes and Celiac Disease Jo...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Authors: Source Type: research
This article summarizes clinical observations and management strategies in pediatric type 1 diabetes (T1D) during the coronavirus disease 2019 (COVID-19) pandemic. Despite initial fears that children with diabetes would, similar to adults with diabetes, be at risk for severe COVID-19, most pediatric patients with a history of T1D who developed COVID-19 had mild disease or were asymptomatic similar to their peers without diabetes. The article also summarizes the use of telemedicine to provide ongoing care for pediatric patients with T1D during the COVID-19 pandemic. Finally, the article highlights important lessons learned ...
Source: The Medical Clinics of North America - Category: General Medicine Authors: Source Type: research
CONCLUSIONS: This is the first article evaluating Pd and Tp-e parameters of children with DKA. In this study, cardiac arrhythmia risk markers were detected to be increased in children with DKA. Therefore, clinicians should be careful about the possibility of development of new arrhythmias during DKA treatment.PMID:34538047 | DOI:10.4274/jcrpe.galenos.2021.2021.0165
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Authors: Source Type: research
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