Nobel Prize in Chemistry Awarded to First All-Female Team for CRISPR Gene Editing

Jennifer Doudna was sound asleep when her phone began buzzing, so she missed the first few calls. When the incessant ringing finally roused her at 3 a.m., it was a reporter who wanted her reaction to the just-awarded Nobel Prize in Chemistry. “Who won?” Doudna asked. “It was a little embarrassing,” Doudna said during a press conference held later in the day when the reporter told her she had been given the prestigious award, along with her collaborator Emmanuelle Charpentier from the Max Planck Institute. “I was really deeply asleep.” Doudna and Charpentier were jointly awarded the 2020 Nobel Prize in Chemistry for their discovery of CRISPR-Cas9, a genome editing technology that allows scientists to deftly edit DNA from virtually any living thing with a precision and ease never before possible. Since they described the technology in 2012, they and other researchers have studied CRISPR for use in possible treatments for human diseases ranging from cancer to HIV as well as in agriculture for ways to make plants drought and pest resistant. Doudna and Charpentier are the first all-female winners of the Chemistry Prize, and Doudna is the first female faculty member at University of California, Berkeley to earn the honor. The news was such a shock that Doudna thought the reporter on the phone had been joking—until she answered a second call early Wednesday morning. It was from her former post-doctoral fellow Martin Jinek, who conducted man...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: news

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AbstractOlfactory and gustatory dysfunctions (OGD) are a frequent symptom of coronavirus disease 2019 (COVID-19). It has been proposed that the neuroinvasive potential of the novel SARS-CoV-2 could be due to olfactory bulb invasion, conversely studies suggest it could be a good prognostic factor. The aim of the current study was to investigate the prognosis value of OGD in COVID-19. These symptoms were recorded on admission from a cohort study of 5868 patients with confirmed or highly suspected COVID-19 infection included in the multicenter international HOPE Registry (NCT04334291). There was statistical relation in multiv...
Source: Infection - Category: Infectious Diseases Source Type: research
Although James Toussaint has never had COVID-19, the pandemic is taking a profound toll on his health. First, the 57-year-old lost his job delivering parts for a New Orleans auto dealership in spring 2020, when the local economy shut down. Then, he fell behind on his rent. Last month, Toussaint was forced out of his apartment when his landlord—who refused to accept federally funded rental assistance—found a loophole in the federal ban on evictions. Toussaint has recently had trouble controlling his blood pressure. Arthritis in his back and knees prevents him from lifting more than 20 pounds, a huge obstacle for...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
Drug Dev Ind Pharm. 2021 May 26:1-32. doi: 10.1080/03639045.2021.1934857. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2 or COVID-19), outbreak was first reported in December 2019 in the Wuhan, China. COVID-19 managed to spread worldwide and so far more than 9.1 million cases and more than 4.7 lakh death has been reported globally. Children, pregnant women, elderly population, immunocompromised patients, and patients with conditions like asthma, diabetes, etc. are highly vulnerable to COVID infection. Currently, there is no treatment available for COVID-19 infection. Traditional m...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Authors: Source Type: research
AbstractThe emergence of data from clinical trials of biologics, the approval of new biologics, and our improved understanding of psoriasis pathogenesis have increased the therapeutic possibilities for the treatment of moderate-to-severe psoriasis. Biologics currently approved for the treatment of psoriasis include tumor necrosis factor inhibitors, interleukin (IL)-17 inhibitors, ustekinumab (an IL-12/23 inhibitor), and IL-23 inhibitors. Data from clinical trials and studies of the safety and efficacy of biologics provide essential information for the personalization of patient care. We discuss the benefits and disadvantag...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
Excessive alcohol use is a common response to coping with stress. Alcohol use increased following the September 11th terrorist attacks and Hurricanes Katrina and Rita. The COVID-19 pandemic is following this same path. However, this pandemic is different in its scope and duration. COVID-19 is associated with both negative health and economic impacts, as well as grief, loss, and prolonged stress and uncertainty. The emotional impact of COVID-19 on women According to the U.S. National Pandemic Emotional Impact Report, compared to men, women reported higher rates of pandemic-related changes in productivity, sleep, mood, healt...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Addiction Alcohol Coronavirus and COVID-19 Women's Health Source Type: blogs
CONCLUSION: VV-ECMO can provide sufficient gas exchange for COVID-19 patients with acute respiratory distress syndrome. However, it is crucial to understand and treat ECMO-related complications.PMID:33748247 | PMC:PMC7953388 | DOI:10.12998/wjcc.v9.i8.1953
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
AbstractOlfactory and gustatory dysfunctions (OGD) are a frequent symptom of coronavirus disease 2019 (COVID-19). It has been proposed that the neuroinvasive potential of the novel SARS-CoV-2 could be due to olfactory bulb invasion, conversely studies suggest it could be a good prognostic factor. The aim of the current study was to investigate the prognosis value of OGD in COVID-19. These symptoms were recorded on admission from a cohort study of 5868 patients with confirmed or highly suspected COVID-19 infection included in the multicenter international HOPE Registry (NCT04334291). There was statistical relation in multiv...
Source: Infection - Category: Infectious Diseases Source Type: research
NEW BRUNSWICK, N.J., February 28, 2021 – Johnson &Johnson (NYSE: JNJ) (the Company) today announced that the U.S. Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices (ACIP) has recommended the first single-shot COVID-19 vaccine, developed by the Janssen Pharmaceutical Companies of Johnson &Johnson, for individuals 18 years of age and older under the Emergency Use Authorization (EUA) issued by the U.S. Food and Drug Administration (FDA). “For more than 130 years, Johnson &Johnson has come to the aid of people during times of crisis, and we believe tod...
Source: Johnson and Johnson - Category: Pharmaceuticals Source Type: news
NEW BRUNSWICK, N.J., February 27, 2021 – Johnson &Johnson (NYSE: JNJ) (the Company) today announced that the U.S. Food and Drug Administration (FDA) has issued Emergency Use Authorization (EUA) for its single-dose COVID-19 vaccine, developed by the Janssen Pharmaceutical Companies of Johnson &Johnson, to prevent COVID-19 in individuals 18 years of age and older. This decision was based on the totality of scientific evidence, including data from the Phase 3 ENSEMBLE study that demonstrated the vaccine was 85 percent effective in preventing severe disease across all regions studied, and showed protection agains...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Our Company Source Type: news
My first exposure to kidney disease and its impact on communities of color occurred when I was in high school. An elderly neighbor, who was like a grandfather to me, had been diagnosed with kidney failure. At about the same time, my older first cousin, who had children about my age, was starting dialysis due to kidney failure attributed to hypertension. She would go on to get a kidney transplant. If you ask any African American, he or she is likely to have at least one relative with kidney disease requiring dialysis or transplantation. Disparities in kidney disease not noted in medical literature until early 1980s When I b...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health care disparities Kidney and urinary tract Source Type: blogs
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