Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis

Pneumococcal meningitis (PM) remains a global public health concern and affects all age groups. If acquired during infancy or childhood, permanent neurofunctional deficits including cognitive impairment, cereb...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research

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Craniopharyngeal canal persistence is a congenital abnormality characterized by a bone canal extending from the nasopharynx to the pituitary fossa. Ascension of microorganisms through the channel can occur, triggering meningitis. AbstractCraniopharyngeal canal persistence is a congenital abnormality characterized by a bone canal extending from the nasopharynx to the pituitary fossa. Ascension of microorganisms through the channel can occur, triggering meningitis.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CLINICAL IMAGE Source Type: research
Conclusions: Half of the patients with suspected CNS infections are diagnosed with a CNS infection, and this was not related to CD4 counts. The best predictor for CNS infections was the CSF leukocyte count.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Coccidioidomycosis is a systemic infection caused by dimorphic fungi Coccidioides spp. endemic to Southwestern United States and Central and South America. A history of residence and travel in these areas is esse...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case report Source Type: research
Sepsis is a severe inflammatory disease with great incidence [1]. There are around 18 million cases of severe sepsis worldwide and 750,000 cases of sepsis in the United States each year. Sepsis can be caused by infection and its clinical symptoms commonly include pneumonia, peritonitis, cholangitis, urinary system infection, cellulitis, meningitis, abscess and so on. The underlying mechanisms of sepsis are not fully elucidated. Complex systemic inflammation, gene polymorphisms, immune dysfunction, abnormal blood coagulation, tissue damage, and the abnormal host response to different infectious pathogens and toxins have bee...
Source: Injury - Category: Orthopaedics Authors: Source Type: research
Teaching Point: Central nervous system adverse effects of cytarabine treatment include aseptic meningitis, myelopathy, and more rarely, encephalopathy, seizures, and cerebellar dysfunction. This case illustrates a cytarabine-induced encephalitis with predominant cerebellar involvement. Published on 2021-09-16 00:00:00
Source: Journal of the Belgian Society of Radiology - Category: Radiology Source Type: research
Volume 12, Issue 1, December 2021, Page 2382-2399 .
Source: Virulence - Category: Virology Authors: Source Type: research
We report an obstetric patient who had a congenital immune system disease and who developed aseptic meningitis following spinal anesthesia.
Source: International Journal of Obstetric Anesthesia - Category: Anesthesiology Authors: Source Type: research
Surg Neurol Int. 2021 Aug 9;12:392. doi: 10.25259/SNI_345_2021. eCollection 2021.ABSTRACTBACKGROUND: Histoplasma capsulatum infection is largely seen in endemic regions; it results in symptomatic disease in
Source: Surgical Neurology International - Category: Neurosurgery Authors: Source Type: research
In conclusion, this study established the best conditions to produce MenW conjugate bulks and showed the efficacy of the obta ined conjugate bulk in induce a good immune response in mice. Further experiments will need to be done to scale up the conjugation reaction and then allow the use of this conjugate in clinical trials.
Source: Glycoconjugate Journal - Category: Biochemistry Source Type: research
CONCLUSION: The majority of the cases involved meningoradiculitis but other, less common, neurological conditions have been described. The clinical signs suggestive of meningitis are not very marked and might delay the diagnosis.PMID:34509348 | DOI:10.1016/j.arcped.2021.08.001
Source: Archives de Pediatrie - Category: Pediatrics Authors: Source Type: research
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