History of malaria control in Rwanda: implications for future elimination in Rwanda and other malaria-endemic countries

Malaria was first reported in Rwanda in the early 1900s with significant heterogeneity and volatility in transmission over subsequent decades. Here, a comprehensive literature review of malaria transmission pa...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Case study Source Type: research

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Purpose of review There is unprecedented movement of people across international borders and parasitic infections, previously restricted to endemic regions, are now encountered in nonendemic areas of the world. Recent findings Migrants may import parasitic infections acquired in their countries of origin. Increasingly, clinicians in nonendemic regions are faced with patients with neglected diseases such as Chagas disease, malaria and strongyloidiasis. There are gaps in knowledge among physicians in nonendemic regions, which lead to missed opportunities for preventive strategies and early treatment. Both primary ...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: TROPICAL AND TRAVEL-ASSOCIATED DISEASES: Edited by Christina M. Coyle Source Type: research
French Guiana (FG) is a French overseas territory where malaria is endemic. The current incidence rate is 0.74 ‰ inhabitants, and Plasmodium vivax is widely predominating even though Plasmodium falciparum is still...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
This study aimed to determine the molecular patterns of the imported malaria infections and recurrence. Blood samples were collected from patients with imported malaria infections during 2016–2018 in Guangxi Zhuang Autonomous Region, China. Next-generation amplicon deep-sequencing approaches were used to assess parasite genetic diversity, multiplexity of infection, relapse, recrudescence, and antimalarial drug resistance. A total of 44 imported malaria cases were examined during the study, of which 35 (79.5%) had recurrent malaria infections within 1 year. The majority (91.4%) had one recurrent malaria episode, where...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Med Sci Monit. 2021 Sep 13;27:e934676. doi: 10.12659/MSM.934676.ABSTRACTMalaria affects more than 3 billion people in 95 countries, with an estimated mortality rate of 400,000 per year. The female Anopheles spp mosquito most commonly transmits malaria, and the main burden of disease is due to Plasmodium falciparum. The most abundant antigen on the sporozoite surface is the Plasmodium falciparum circumsporozoite protein (PfCSP). PfCSP is required for parasite development and attachment to host hepatocytes. The first potential protein vaccine, RTS,S/ASO1, consists of a recombinant fusion antigen based on PfCSP. Initial findi...
Source: Medical Science Monitor - Category: Research Authors: Source Type: research
Biochem Biophys Res Commun. 2021 Aug 27;577:58-63. doi: 10.1016/j.bbrc.2021.08.052. Online ahead of print.ABSTRACTThere is an urgent need for a malaria vaccine that can prevent severe disease in young children and adults. Despite earlier work showing an immunological mechanism for preventing infection and reducing disease severity, there is currently no reliable vaccine that can provide durable protection. In part, this may reflect a limited number of ways that the host can respond to the NANP repeat sequences of circumsporozoite protein (CSP) in the parasite. In addition, it may reflect antigenic escape by the parasite fr...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Source Type: research
Brucellosis is an important neglected bacterial zoonotic disease that has been affecting animals and humans for decades. Malaria has been considered major cause of illness in tropical areas, including Ethiopia...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
Malaria eradication requires a combined effort involving all available control tools, and these efforts would be complemented by an effective vaccine. The antigen targets of immune responses may show polymorph...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Malaria and schistosomiasis present considerable disease burden in tropical and sub-tropical areas and severity is worsened by co-infections in areas where both diseases are endemic. Although pathogenesis of t...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research Source Type: research
In many endemic areas, Plasmodium vivax malaria is predominantly a disease of young adults and children. International recommendations for radical cure recommend fixed target doses of 0.25 or 0.5 mg/kg/day of pri...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
While insecticide-based vector control can effectively target vector species in areas of high malaria endemicity, such as Anopheles gambiae in Africa, residual disease transmission can occur. Understanding the po...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
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