The role of hypertension and renin-angiotensin-aldosterone system inhibitors in bleomycin-induced lung injury

This study clarified the impact of hypertension and the administration of renin-angiotensin-aldosterone system (RAAS) inhibitors on the occurrence of bleomycin-induced lung injury (BLI). We retrospectively analyzed the data of 190 patients treated with bleomycin-containing chemotherapy. Age ≥65 years and a history of hypertension were significant factors for BLI onset. BLI occurrence was lower in patients who used RAAS inhibitors.

Source: Clinical Lymphoma, Myeloma and Leukemia - October 8, 2020 Category: Hematology Authors: Ryujiro Hara, Makoto Onizuka, Sawako Shiraiwa, Kaito Harada, Yasuyuki Aoyama, Daisuke Ogiya, Masako Toyosaki, Rikio Suzuki, Sinichiro Machida, Ken Ohmachi, Yoshiaki Ogawa, Hiroshi Kawada, Shigeki Watanabe, Akira Miyajima, Ryota Masuda, Masayuki Iwazaki, M Tags: Original Study Source Type: research