Proteomics reveals region-specific hemostatic alterations in response to mechanical ventilation in a preterm lamb model of lung injury

Preterm infants often require assisted ventilation, however ventilation when applied to the immature lung can initiate ventilator-induced lung injury (VILI). The biotrauma which underscores VILI is largely undefined, and is likely to involve vascular injury responses, including hemostasis. We aimed to use a ventilated, preterm lamb model to: (1) characterize regional alterations in hemostatic mediators within the lung and (2) assess the functional impact of protein alterations on hemostasis by analyzing temporal thrombin generation.

Source: Thrombosis Research - October 7, 2020 Category: Hematology Authors: Christine Schmid, Vera Ignjatovic, Boyuan Pang, Shuai Nie, Nicholas A. Williamson, David G. Tingay, Prue M. Pereira-Fantini Source Type: research