Negative Impact of Cytomegalovirus Reactivation on Survival in Adult Patients with Aplastic Anemia After an Allogeneic Hematopoietic Stem Cell Transplantation: A Report from Transplantation-Related Complication and Adult Aplastic Anemia Working Groups of the Japan Society for Hematopoietic Cell Transplantation

Cytomegalovirus (CMV) infection is a major infectious complication following an allogeneic hematopoietic stem cell transplantation (allo-HSCT). CMV end-organ disease is a significant cause of morbidity and mortality following an allo-HSCT despite advances in the early diagnosis and managements of CMV infection (1-5). Early detection of CMV reactivation through CMV antigenemia or polymerase chain reaction (PCR) assay and the use of preemptive antiviral therapy using ganciclovir (GCV), valganciclovir (VGCV), or foscarnet (FOS) decreased the incidence of CMV end-organ disease within the first 100 days after allo-HSCT to

Source: Biology of Blood and Marrow Transplantation - October 8, 2020 Category: Hematology Authors: Katsuto Takenaka, Yasushi Onishi, Takehiko Mori, Tsuneaki Hirakawa, Yuuma Tada, Naoyuki Uchida, Takeshi Kobayashi, Yoshinobu Kanda, Yukiyasu Ozawa, Shuichi Ota, Hiroatsu Iida, Kentaro Fukushima, Takafumi Kimua, Takahiro Fukuda, Yoshiko Atsuta, Keitaro Mat Source Type: research