High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids

Preclinical identification of compounds at risk of causing drug induced liver injury (DILI) remains a significant challenge in drug development, highlighting a need for a predictive human system to study complicated DILI mechanism and susceptibility to individual drug. Here, we established a human liver organoid (HLO) based screening model for analyzing DILI pathology at organoid resolution.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research