High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids
Preclinical identification of compounds at risk of causing drug induced liver injury (DILI) remains a significant challenge in drug development, highlighting a need for a predictive human system to study complicated DILI mechanism and susceptibility to individual drug. Here, we established a human liver organoid (HLO) based screening model for analyzing DILI pathology at organoid resolution.
Source: Gastroenterology - Category: Gastroenterology Authors: Tadahiro Shinozawa, Masaki Kimura, Yuqi Cai, Norikazu Saiki, Yosuke Yoneyama, Rie Ouchi, Hiroyuki Koike, Mari Maezawa, Ran-Ran Zhang, Andrew Dunn, Autumn Ferguson, Shodai Togo, Kyle Lewis, Wendy Thompson, Akihiro Asai, Takanori Takebe Source Type: research