Comparative Safety and Effectiveness of Vedolizumab to Tumor Necrosis Factor Antagonist Therapy for Ulcerative Colitis

We aimed to compare safety and effectiveness of vedolizumab to tumor necrosis factor (TNF)-antagonist therapy in ulcerative colitis in routine practice.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research

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When Joe Silverman developed Crohn’s disease at age 21, the symptoms started out mild. While the sight of blood in his stools initially freaked him out, what really bothered him was the frequent abdominal pain and bloating that occurred as his condition progressed to moderate and then severe. Dietary changes didn’t make a difference, so he began taking prescription oral anti-inflammatory drugs that are often used to treat certain bowel diseases, which alleviated but didn’t eliminate his discomfort. He started using prescription steroid suppositories to cope with flare-ups of the inflammatory bowel disease...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: news
Genes, Vol. 12, Pages 1477: Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could Distinguish between Ulcerative Colitis and Crohn’s Disease Genes doi: 10.3390/genes12101477 Authors: Daša Jevšinek Skok Nina Hauptman Miha Jerala Nina Zidar Ulcerative colitis (UC) and Crohn’s disease (CD) are characterized by an imbalance between pro-inflammatory and anti-inflammatory cytokines, interfering with the resolution of inflammation. Due to the crucial role of cytokines, new insights into their profiles in UC and CD would help to improve our understanding of pathogenesis and enabl...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Kubinski Inflammatory bowel diseases (IBD), subdivided into Crohn’s disease (CD) and ulcerative colitis (UC), are chronic diseases that are characterized by relapsing and remitting periods of inflammation in the gastrointestinal tract. In recent years, the amount of research surrounding digital health (DH) and artificial intelligence (AI) has increased. The purpose of this scoping review is to explore this growing field of research to summarize the role of DH and AI in the diagnosis, treatment, monitoring and prognosis of IBD. A review of 21 articles revealed the impact of both AI algorithms and DH technologies;...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
The oral colon-targeting drug delivery vehicle is vital for the efficient application of curcumin (Cur) in ulcerative colitis (UC) treatment because of its lipophilicity and instability in the gastrointestinal...
Source: Chinese Medicine - Category: Complementary Medicine Authors: Tags: Research Source Type: research
CONCLUSIONS: The present study demonstrated that the ITGB4 (c.C2503G; p.P835A) and MUC3A (c.C1019T; p.P340L) mutations may be the potential causative variants in a patient with UC associated with PSC and SSA. TP53 (c.86delA; p.N29Tfs ∗ 15) mutation may be associated with SSA in this patient.PMID:34545326 | PMC:PMC8449715 | DOI:10.1155/2021/9936932
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
The risk of inflammatory bowel disease (IBD) within families continues to be elucidated, and data are lacking on this topic in Asian countries. In this issue of Clinical Gastroenterology and Hepatology, Kim and colleagues1 conducted a retrospective cohort study within the South Korea National Health Insurance Database, from 2002-2017. This data source is derived from the universal health system in South Korea, is population-based, and specifically includes family history information. From a cohort of nearly 22 million individuals, the investigators identified 45,717 with ulcerative colitis and 17,848 with Crohn ’s di...
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Issue Highlights Source Type: research
Am J Transl Res. 2021 Aug 15;13(8):9701-9707. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the role of Shenling Baizhu powder as an adjuvant therapy on the serum TH1 of elderly patients with ulcerative colitis complicated by bloody purulent stool.METHODS: A total of 70 elderly patients with ulcerative colitis complicated by bloody purulent stool presenting to our hospital from June 2018 to October 2019 were enrolled and equally randomized. Patients were administered mesalazine enteric-coated tablets in the control group, and patients were additionally treated with Shenling Baizhu powder. The main clinical symptom sco...
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research
CONCLUSIONS: This study reflects the multicomponent, multitarget, and multipathway characteristics of the action mechanism of GJHQHLRSD in treating UC. Furthermore, it helps better understand the TCM therapeutic principle of Han Re Bing Yong Fa and explore novel candidate drug targets for UC treatment.PMID:34539797 | PMC:PMC8445727 | DOI:10.1155/2021/1925718
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Source Type: research
World J Gastroenterol. 2021 Aug 28;27(32):5351-5361. doi: 10.3748/wjg.v27.i32.5351.ABSTRACTThe close relationship of medicine with technology and the particular interest in this symbiosis in recent years has led to the development of several computed artificial intelligence (AI) systems aimed at various areas of medicine. A number of studies have demonstrated that those systems allow accurate diagnoses with histological precision, thus facilitating decision-making by clinicians in real time. In the field of gastroenterology, AI has been applied in the diagnosis of pathologies of the entire digestive tract and their attache...
Source: World Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Am J Transl Res. 2021 Aug 15;13(8):9701-9707. eCollection 2021.ABSTRACTOBJECTIVE: To investigate the role of Shenling Baizhu powder as an adjuvant therapy on the serum TH1 of elderly patients with ulcerative colitis complicated by bloody purulent stool.METHODS: A total of 70 elderly patients with ulcerative colitis complicated by bloody purulent stool presenting to our hospital from June 2018 to October 2019 were enrolled and equally randomized. Patients were administered mesalazine enteric-coated tablets in the control group, and patients were additionally treated with Shenling Baizhu powder. The main clinical symptom sco...
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research
More News: Gastroenterology | Inflammatory Bowel Disease | Ulcerative Colitis