Association of Severe Hypoglycemia with All-Cause Mortality and Complication Risks among Patients with Type 2 Diabetes Mellitus in China

The optimization of glycemic control is a critical strategy to limit the deleterious effects of diabetes among patients with diabetes mellitus (DM), aiming to prevent premature mortality and diabetes-related complications, especially the microvascular diseases. However, the use of antidiabetic medicines also increases the risk of hypoglycemia as a common side effect, particularly for intensive glucose-lowering regimens such as insulin and sulphonylurea[1,2]. Although most hypoglycemia is mild and self-managed with symptoms such as sweating, dizziness or headache, there are some serious hypoglycemic episodes which may result in coma, brain damage or both, and can adversely affect blood-brain barrier integrity [3,4].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research