Functional benefits of corticosteroid and IVIG combination therapy in a coronary artery endothelial cell model of Kawasaki disease

Kawasaki disease (KD) is the most common pediatric systemic vasculitides of unknown etiology. Recent clinical studies led to reappraisal of the usefulness of initial combination therapy of intravenous immunogl...
Source: Pediatric Rheumatology - Category: Rheumatology Authors: Tags: Research article Source Type: research

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CONCLUSION MIS-C encompasses a broad phenotypic spectrum with clinical and laboratory features distinct from KD and MAS.FUNDING This work was supported by the National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases; the National Institute of Allergy and Infectious Diseases; Rheumatology Research Foundation Investigator Awards and Medical Education Award; Boston Children’s Hospital Faculty Career Development Awards; the McCance Family Foundation; and the Samara Jan Turkel Center.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Authors: SPECIAL ISSUE: FOCUS ON PEDIATRIC CARDIOLOGY, Conti G, Giannitto N, De Luca FL, Salpietro A, Oreto L, Viola I, Ceravolo A, Nicocia G, Sio A, Romeo M, Ceravolo G, Cuppari C, Calabrò MP, Chimenz R Abstract Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology. It has a self-limiting course and so far, represents the most common cause of coronary heart disease acquired in children aged between 6 months and 5 years. The inflammatory process can involve the coronary arteries with the formation of aneurysms and thrombotic occlusions with the risk of sudden death, especially in infants....
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Kawasaki disease (KD) patients’ resistance to treatment with intravenous immunoglobulins (IVIG) places them at high risk for an unfavorable progression of the disease. In these patients, there has been little evidence that alternative treatments are effective. Nevertheless, biologicals such as an interleukin-1-receptor blocker and tumor-necrosis-factor-α inhibitors increasingly have been used. If the patient does not respond to one of these therapeutics, a combination of 2 biologicals might be an alternative, but this is not yet generally accepted due to the potentially increased risk of infection. Here we repo...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Instructive Cases Source Type: research
Addition of corticosteroids to initial intravenous immunoglobulin treatment appears to reduce the rate of coronary-artery abnormalities in high-risk patients with Kawasaki disease.Reuters Health Information
Source: Medscape Radiology Headlines - Category: Radiology Tags: Cardiology News Source Type: news
WEDNESDAY, Aug. 19, 2020 -- Adding corticosteroids to initial intravenous immunoglobulin seems beneficial for preventing coronary artery abnormalities in high-risk patients with Kawasaki disease (KD), according to a study published online Aug. 19 in...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
(American Heart Association) For children with Kawasaki disease with higher risk of developing blood vessel complications, adding corticosteroids to standard intravenous immunoglobulin treatment could boost initial treatment response and prevent complications.Researchers used real-world data from large, nationwide Japanese Kawasaki disease surveys to compare combination therapy with the standard treatment.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
AbstractCardiac involvement is very rare in patients with Henoch-Sch önlein purpura (HSP). In this case study, we present an 8-year-old girl presenting with HSP-induced myocarditis and thrombus in the right atrium and HSP nephritis. To date, 15 cases of HSP-related cardiac involvement have been reported in the PubMed/MEDLINE, Scopus, and Google Scholar databases. Th ese cases, together with our case, are included in this review. We excluded those patients with other rheumatologic diseases (acute rheumatic fever, acute post-streptococcal glomerulonephritis, Kawasaki disease) accompanied by HSP. Three were children and ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
(CNN) — The US Centers for Disease Control and Prevention is preparing to release an alert warning doctors to be on the lookout for a dangerous inflammatory syndrome in children that could be linked to coronavirus infection, a CDC spokesman told CNN Tuesday. The syndrome, marked by persistent fever, inflammation, poor function in one or more organs, and other symptoms similar to shock, was first reported by New York officials. More states began reporting diagnoses of the syndrome this week. An informal panel of pediatricians organized by Boston Children’s Hospital have dubbed the mysterious illness “Pedia...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Featured Health Syndicated CBSN Boston Boston Children's Hospital CNN Coronavirus Source Type: news
A 21-year-old female presented with chief complaints of abdominal pain and fever for 3  months. Family history was not significant. Her blood pressure was 190/100 mmHg. Auscultation revealed an abdominal bruit but femoral pulses were normal. She had tachycardia (140 beats/min). Laboratory parameters showed elevated inflammatory bio-markers like C-reactive protein (15.0 mg/l) and erythrocyte sedimentation rate (90 mm/h). Computed tomography angiography (CTA) was advised and it revealed significant narrowing of descending aorta due to mural thickening. Venous phase of CTA demonstrated ‘Doubl...
Source: QJM - Category: Internal Medicine Source Type: research
Authors: Chang LS, Kuo HC Abstract Introduction: Kawasaki disease (KD) is a form of systemic vasculitis that can lead to complications of coronary artery lesions (CAL). Diagnosis without delay and treatment with intravenous immunoglobulin (IVIG) are vital for a better prognosis. Anti-inflammatory drugs are generally used empirically in pediatric patients as off label. Corticosteroids are effective with anti-inflammatory effects applied in vasculitis.Areas covered: The timing of corticosteroid treatment in KD has been widely discussed by scholars. Some corticosteroids may still be effective which could be useful for...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
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