A Review of New Medications and Future Directions of Medical Therapies in Glaucoma.

CONCLUSION: Three new topical glaucoma medications offer additional treatment options for patient with glaucoma. Further research is needed to better understand the utility of sustained release formulations in the treatment of glaucoma. PMID: 33019870 [PubMed - as supplied by publisher]
Source: Seminars in Ophthalmology - Category: Opthalmology Tags: Semin Ophthalmol Source Type: research

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AbstractGlaucoma is an optic neuropathy that gradually steals the patient's sight by damaging the optic nerve head (which is responsible for transferring images from the eye to the brain). Causing an estimated 12.3% of global blindness, glaucoma is considered as the first leading cause of irreversible blindness in the world. This paper presents a novel eye fundus image analysis algorithm for the automatic measurement of fundus related glaucoma indicators; Cup to Disc Ratio (CDR), verification of the ISNT rule, Disc Damage Likelihood Scale (DDLS), and the classification of the input fundus into glaucoma or non-glaucoma case...
Source: Australasian Physical and Engineering Sciences in Medicine - Category: Biomedical Engineering Source Type: research
CONCLUSION: MIGS can increase the outflow facility of the eye in patients with glaucoma. Though ELT had the lowest impact on the aqueous outflow among the studied procedures in this study. The new test can help in the evaluation of current and further development of new MIGS in the future. PMID: 32967033 [PubMed - as supplied by publisher]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Characterization of a novel mutation in the MYOC gene in a Chinese family with primary open‑angle glaucoma. Mol Med Rep. 2020 Aug 19;: Authors: Fan W, Li W, Duan C, Zhang W, Guo Y, Chen F Abstract Although primary open‑angle glaucoma (POAG)‑related mutations in the myocilin (MYOC) gene have been reported, the underlying associations remain poorly understood. In the present study, the relationship between a MYOC mutation and POAG was investigated using ophthalmic examination and total exon gene sequencing in a Chinese family comprised of 5 individuals with POAG and 15 unaffected individuals. Patho...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
This study provides new insights into mechanisms of RGC degeneration after ON injury, as well as central nervous system (CNS) neurodegeneration, since the retina is an extension of the CNS. These new insights will lead to novel therapeutic targets for retinal and CNS neurodegeneration. PMID: 32971066 [PubMed - as supplied by publisher]
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research
AbstractGlaucoma is a chronic disease that threatens eye health and can cause permanent blindness. Since there is no cure for glaucoma, early screening and detection are crucial for the prevention of glaucoma. Therefore, a novel method for automatic glaucoma screening that combines clinical measurement features with image-based features is proposed in this paper. To accurately extract clinical measurement features, an improved UNet++ neural network is proposed to segment the optic disc and optic cup based on region of interest (ROI) simultaneously. Some important clinical measurement features, such as optic cup to disc rat...
Source: Medical and Biological Engineering and Computing - Category: Biomedical Engineering Source Type: research
Glaucoma remains the world’s leading cause of irreversible blindness and though intraocular pressure (IOP) is the most prevalent risk factor and only reliable therapeutic target, a number of systemic disease associations have been reported. Metabolic syndrome (MetS) is a constellation of findings that includes systemic hypertension, abdominal obesity, glucose intolerance, and dyslipidemia. MetS is becoming increasingly common worldwide, with prevalence up to 40% in some countries. Not only is MetS a significant cause of morbidity, but it is also associated with an increase in all-cause mortality. Reports have been co...
Source: Journal of Glaucoma - Category: Opthalmology Tags: Review Articles Source Type: research
AbstractAutomatic grading of retinal blood vessels from fundus image can be a useful tool for diagnosis, planning and treatment of eye. Automatic diagnosis of retinal images for early detection of glaucoma, stroke, and blindness is emerging in intelligent health care system. The method primarily depends on various abnormal signs, such as area of hard exudates, area of blood vessels, bifurcation points, texture, and entropies. The development of an automated screening system based on vessel width, tortuosity, and vessel branching are also used for grading. However, the automated method that directly can come to a decision b...
Source: Journal of Medical Systems - Category: Information Technology Source Type: research
Glia-driven neuroinflammation promotes neuron injury in glaucoma that is a chronic neurodegenerative disease of the optic nerve and a leading cause of irreversible blindness. Although therapeutic modulation of...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
Conclusion: Awareness and knowledge of glaucoma in this population is low. These findings suggest that there is a need for an efficient information and education strategy to be designed and conducted to increase the awareness and knowledge of glaucoma so that early detection can be made and effective management of individuals with this condition can be delivered. PMID: 32802004 [PubMed - in process]
Source: The Scientific World Journal - Category: Science Tags: ScientificWorldJournal Source Type: research
Authors: Emrani E Abstract Glaucoma is the leading cause of irreversible blindness in Germany and in the world. Due to the multifactorial genesis of the disease, there are multiple therapeutic approaches for preventing its progression. The goal of the commonly used topical glaucoma medication is to reduce the intraocular pressure and therefore prevent further damage to the optic nerve. There are different medications of various pharmacological classes that are intended to reduce intraocular pressure, namely, β-adrenergic antagonists, adrenergic agonists, parasympathomimetic agents, prostaglandin analogues, car...
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
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