Development and Validation of a Deep Learning Algorithm for Auto-delineation of Clinical Target Volume and Organs at Risk in Cervical Cancer Radiotherapy
Cervical cancer is the second most common cancer in women aged 15 to 44 years worldwide [1,2]. Intensity-modulated radiation therapy (IMRT) has become the preferred radiotherapy method for locally advanced cervical cancer treatment . Accurate delineation of the clinical target volume (CTV) and organ-at-risk (OAR) is one of the essential steps for successful IMRT delivery. Such delineation is conventionally performed by radiotherapy oncologists through laborious manual delineation. The delineation is time-consuming  and heavily relies on the radiotherapy oncologists ’ experience.
ConclusionWe trained and cross-validated an RID predictive model with high discriminative ability at both 6 and 12 months after RT. We expect to improve the predictive power of this model by enlarging the number of training datasets.
Conditions: Cervical Carcinoma; Endometrial Carcinoma; Endometriosis; Pelvic Inflammatory Disease Interventions: Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Radiation: Radiation Therapy Sponsors: Mayo Clinic; National Cancer Institute (NCI) Not yet recruiting
ConclusionChemoradiation with a LN-directed SIB for women with LN-positive cervical cancer is well tolerated and is associated with excellent oncologic outcomes.SummaryIn this report, we evaluated the oncologic efficacy and adverse events associated with definitive chemoradiotherapy with a simultaneous integrated boost to grossly involved lymph nodes for women with lymph node –positive cervical cancer. We have identified acceptable rates of adverse events and excellent oncologic outcomes, even in a very high risk cohort of women with cervical cancer.
This study evaluated the feasibility of atlas-ba...
The use of concurrent doublet chemotherapy with radiation for locoregionally advanced cervical cancer (LACC) is limited by gastrointestinal and hematologic toxicity. By reducing radiation dose to bowel and bone marrow, image-guided intensity modulated radiation therapy (IG-IMRT) may improve chemotherapy tolerance. The goal of this study was to determine whether IG-IMRT could lead to improved tolerance to concurrent cisplatin and gemcitabine for LACC.
The use of concurrent doublet chemotherapy with radiation for locoregionally advanced cervical cancer (LACC) is limited by gastrointestinal and hematologic toxicity. By reducing radiation dose to bowel and bone marrow, image guided intensity modulated radiation therapy (IG-IMRT) may improve chemotherapy tolerance. The goal of this study was to determine whether IG-IMRT could lead to improved tolerance to concurrent cisplatin and gemcitabine for LACC.
Conclusions: Our findings suggest that IMRT may represent a viable alternative in delivering the boost in patients diagnosed with gynaecological cancer not amenable to ICBRT. PMID: 32010217 [PubMed]
Conclusions: Our study confirms that the combination of IMRT and PDR-BT can be considered an effective treatment for cervical cancer, ensuring high local control, despite the high percentage of locally advanced disease. PMID: 31969909 [PubMed]
Abstract PURPOSE: To develop and evaluate an automatic intensity-modulated radiation therapy (IMRT) program for cervical cancer, including a Convolution Neural Network (CNN)-based prediction model and an automated optimization strategy. METHODS: A CNN deep learning model was trained to predict a patient-specify set of IMRT objectives based on overlap volume histograms (OVH) and high-quality plan of previous patients. A total of 140 cervical cancer patients were enrolled in this study, including 100 patients in the training set, 20 patients in the validation set and 20 patients in the testing set. The input of...
Abstract Positron emission tomography (PET) with 18F-fluordeoxyglucose (FDG) in combination with computed tomography (CT) is well established for the diagnostic work-up of patients with head and neck cancer. Possible applications include the detection of an occult primary tumor metastatic to cervical nodes, locoregional staging, assessment of treatment response to external beam irradiation (also in combination with chemotherapy), and surveillance for recurrence. The success of high-precision irradiation techniques such as intensity-modulated radiation therapy (IMRT) appears to be improved by delineating the tumor ...