GSE155476 Comparison of gene expression profile of human blastocyst between young and aging infertility patients

Contributors : Yuta Kawagoe ; Ikko Kawashima ; Yorino Sato ; Naoki Okamoto ; Kazuei Matsubara ; Kazuhiro KawamuraSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe pregnancy rate of women decreases with age due to declining quality of oocytes and embryos. However, there is no established method to improve pregnancy rate in aging women. Here, we performed microarray analysis for detecting candidate genes affected the quality of aging embryos. Based on microarray analysis using young and aging human embryos at the same morphological grade, 820 genes showed> 5-fold change in aging human blastocysts. Among these genes, C-X-C motif chemokine 5 (CXCL5), one of SASP factors, showed 7.2-fold increases in aging human blastocysts. These findings indicate CXCL5, one of senescence-associated secretory phenotype (SASP) factors, partially responsible for the decline in embryo implantation potentia.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research