Syd/JIP3 controls tissue size by regulating Diap1 protein turnover downstream of Yorkie/YAP.

This study provides mechanistic insights into the recent and perplexing link between JIP3 mutations and organ size defects in mammals, including in humans where de novo JIP3 variants are associated with microcephaly.
PMID: 33022230 [PubMed - as supplied by publisher]

Source: Developmental Biology - October 2, 2020 Category: Biology Authors: Ahmad V, Vadla GP, Chabu CY Tags: Dev Biol Source Type: research