Genetically encoded thiol redox-sensors in the zebrafish model: lessons for embryonic development and regeneration.

We describe how such observations have prompted insight into regulation and downstream effects of redox alterations during tissue differentiation, morphogenesis and regeneration. We also discuss the properties of the different sensors and their consequences for the interpretation of in vivo imaging results. Finally, we highlight open questions and additional research fields that may benefit from further application of such sensor systems in zebrafish models of development, regeneration and disease.
PMID: 33021959 [PubMed - as supplied by publisher]

Source: Biological Chemistry - October 7, 2020 Category: Chemistry Tags: Biol Chem Source Type: research