Serum vitamin D level is related to disease progression in primary biliary cholangitis.

Serum vitamin D level is related to disease progression in primary biliary cholangitis. Scand J Gastroenterol. 2020 Oct 06;:1-8 Authors: Wang Z, Peng C, Wang P, Sui J, Wang Y, Sun G, Liu M Abstract BACKGROUND AND AIM: A nonskeletal role of vitamin D in primary biliary cholangitis (PBC) patients is not yet clear. The purpose of this study is to investigate the serum vitamin D level in patients with PBC and to explore whether serum vitamin D level is related to disease progression. METHODS: The serum levels of 25(OH)D3 were measured in 185 PBC patients and 141 healthy controls. The association with vitamin D levels and disease progression, particularly natural course, was assessed. RESULTS: Serum vitamin D levels were measured in 185 patients with PBC. The mean level of vitamin D in advanced stage patients was lower than that in early stage patients (9.15 ± 5.33 ng/ml vs. 13.68 ± 6.33 ng/ml, p = .000). In the follow-up patients, the vitamin D level in the taken calcitriol patients showed an upward trend, while the un-taken calcitriol patients was opposite. Besides, vitamin D levels were correlated with the changes of bilirubin, albumin (ALB) and APRI (p
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

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