Viruses, Vol. 12, Pages 1137: Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis

Viruses, Vol. 12, Pages 1137: Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis Viruses doi: 10.3390/v12101137 Authors: B.M.C.R. Wimalasiri-Yapa Harith E. Yapa Xiaodong Huang Louise M. Hafner Tony J. Kenna Francesca D. Frentiu Dengue, chikungunya and Zika viruses share similar disease features, rendering them difficult to distinguish clinically. Incapacitating arthralgia/arthritis is a specific manifestation associated with chikungunya virus infection. However, the profile of arthralgia/arthritis in Zika virus (ZIKV) cases has not been well characterized. Articles were extracted from PubMed and Scopus databases reporting original data from patients with arthralgia/arthritis, according to the Cochrane Collaboration. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, 137 articles reporting ZIKV-associated joint symptoms were reviewed. Arthralgia was more frequently reported (n = 124 from case studies, n = 1779 from population-based studies) than arthritis (n = 7 and n = 121, respectively). Arthralgia was resolved in <1 week in 54%, and within 1–2 weeks in 40% of cases. The meta-analysis of cases in population-based studies identified a pooled prevalence of 53.55% for arthralgia. The pooled prevalence of arthralgia/arthritis during outbreaks depended on the geographic location, with a higher joint symptom burden observed in the Americas compared to South East Asia (Brazil: 6...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research