Nanocarrier-based Drug Delivery System for Cancer Therapeutics: A Review of the Last Decade.

Nanocarrier-based Drug Delivery System for Cancer Therapeutics: A Review of the Last Decade.
Curr Med Chem. 2020 Oct 05;:
Authors: Sohail M, Guo W, Li Z, Xu H, Zhao F, Chen D, Fu F
Abstract
In recent years, due to the shortcomings of conventional chemotherapy, such as poor bioavailability, low treatment index and unclear side effects, the focus of cancer research has shifted to new nanocarriers of chemotherapeutic drugs. By using biodegradable materials, nanocarriers generally have the advantages of good biocompatibility, low side effects, targeting, controlled release profile, and improved efficacy. And more to the point, nanocarrier based anti-cancer drug delivery systems clearly show the potential to overcome the problems associated with conventional chemotherapy. In order to promote the deepening of research and development in this field, we herein summarized and analyzed various nanocarrier based drug delivery systems for cancer therapy, including the concepts, types, characteristics and preparation methods. The active and passive targeting mechanisms of cancer therapy were also included, along with a brief introduction of the research progress of nanocarriers used for anti-cancer drug delivery in the past decade.
PMID: 33019919 [PubMed - as supplied by publisher]

Source: Current Medicinal Chemistry - October 4, 2020 Category: Chemistry Authors: Sohail M, Guo W, Li Z, Xu H, Zhao F, Chen D, Fu F Tags: Curr Med Chem Source Type: research