Chronic endometritis and altered embryo implantation: a unified pathophysiological theory from a literature systematic review

ConclusionThis is the first summary of evidence on CE pathophysiology and its relationship with infertility. Understanding the CE pathophysiology could improve our knowledge in embryo transfer success.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research

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In this study, the effects of NAM and MNAM on metabolic and endocrine abnormalities were evaluated in the adipose and ovarian tissues of a letrozole-induced rat model of PCOS. Our results showed that MNAM and NAM reversed abnormal estrous cycle and reduced the serum testosterone levels and CYP17A1 gene expression. Furthermore, all therapeutic factors improved HOMA-IR after treatment and NAM significantly increased the expression of GLUT4 and decreased the gene expression of visfatin. Also, MNAM diminished the gene expression of visfatin and resistin. It is noteworthy that all the therapeutic factors successfully activated ...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
Publication date: Available online 19 May 2020Source: Journal of Clinical &Translational EndocrinologyAuthor(s): Tarek M Hussein, Dalia Abd Elmoaty Elneily, Fatma Mohamed Abdelfattah Elsayed, Lama M. El-Attar
Source: Journal of Clinical and Translational Endocrinology - Category: Endocrinology Source Type: research
Abnormal uterine bleeding (AUB) affects up to two thirds of women on anticoagulation (AC) therapy. In women on AC for venous thromboembolism (VTE), AUB is linked to recurrent VTE, likely due to interrupted therapy. Treatment options for anticoagulant-associated AUB (AA-AUB) are limited, as estrogen-containing treatments increase thrombotic risk and endometrial ablation or hysterectomy lead to infertility. While uterine artery embolization (UAE) is a well-established treatment for symptomatic fibroids, its role in acute AA-AUB is limited to case reports.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific e-Poster Source Type: research
Authors: Nourollahpour Shiadeh M, Cassinerio E, Modarres M, Zareiyan A, Hamzehgardeshi Z, Behboodi Moghadam Z Abstract β-thalassaemia major (BTM) has a high prevalence worldwide and is associated with considerable morbidity and mortality. The aim of this review is to provide an illustrative overview of the reproductive health and pregnancy related issues in females with β-thalassaemia. A literature search was performed in four international databases (1980-2018) to identify the potentially relevant articles. Common reproductive health disorders are hypo-gonadotrophic hypogonadism, infertility, delayed or ...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
CONCLUSION: Today IPAA is the gold standard. The IRA is indicated in selected patients where they meet the following requirements: normal sphincter tone, absence of severe perineal disease, rectum does not actively involved by the disease, absence of dysplasia or cancer. It is also indicated in patients who refuse an ileostomy and it can be proposed as a possible interim procedure in young women, because it does not need a pelvic dissection and because the risk of infertility is minimal or absent when compared to IPAA. Because the risk of cancer is higher, patients undergoing IRA must be adequately informed about the risk,...
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
The objective of the present study was to review the pathophysiology of APS and its association with female infertility. A bibliographic review of articles of the past 20 yearswas performed at the PubMed, Scielo, and Bireme databases. Antiphospholipid antibody syndrome may be associated with primary infertility, interfering with endometrial decidualization and with decreased ovarian reserve. Antiphospholipid antibodies also have direct negative effects on placentation, when they bind to the trophoblast, reducing their capacity for invasion, and proinflammatory effects, such as complement activation and neutrophil recruitme...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
A tubo-ovarian abscess (TOA) is an emergent and potentially life-threatening illness. Rapid administration of antibiotics, interventional radiology abscess drainage, and/or gynecologic surgery are critical interventions. The goal is to prevent abscess rupture, which can lead to peritonitis, severe sepsis, recurrent hospitalizations, and, in rare circumstances, death [1]. Although mortality from TOA in the U.S. is uncommon, the result of an untreated TOA can have lasting damaging effects to pelvic organs and increase the risk of infertility, ectopic pregnancy, ovarian vein thrombosis, and chronic pelvic pain [2].
Source: Journal of Adolescent Health - Category: Child Development Authors: Tags: Editorial Source Type: research
The role of genetic thrombophilia screening for identifying a hypercoagulable state in the management of venous thromboembolism. We searched MEDLINE and EMBASE from 1995 to 2017, the websites of the professional bodies including American Society of Hematology, British Society of Hematology, International Society of Thrombosis and Hemostasis, College of American Pathologists, American College of Medical Genetics, and American Society of obstetrics and gynecology for their clinical practice guidelines. We used search strategy terms – venous thromboembolism, inherited, thrombophilia, and hypercoagulable state. Thromboph...
Source: Blood Coagulation and Fibrinolysis - Category: Hematology Tags: SHORT COMMUNICATION Source Type: research
Authors: Vanni VS, De Lorenzo R, Privitera L, Canti V, Viganò P, Rovere-Querini P Abstract Introduction: Systemic Autoimmune Diseases (SADs) include systemic lupus erythematosus, antiphospholipid antibody syndrome, rheumatoid arthritis, systemic sclerosis, Sjogren's syndrome, mixed connective tissue disease, idiopathic inflammatory myopathies and vasculitis. SADs often occur in women of childbearing age and can affect fertility. Both infertility treatments and fertility preservation techniques are thus often indicated. Areas covered: The literature regarding the safety of fertility-related drugs for both fer...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Authors: Kydonopoulou K, Rousso D, Ilonidis G, Mandala E Abstract Glycoprotein Ia (GPIa), also known as integrin alpha 2 (ITGA2), together with GPIIa (ITGB1), form the heterodimer integrin α2β1. This complex is a major collagen receptor on the membrane of platelets, which is involved in thrombus formation through platelet adhesion and activation. PMID: 31184100 [PubMed - as supplied by publisher]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
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