Panton-valentine leucocidin carrying Staphylococcus aureus causing necrotizing pneumonia inactivates the JAK/STAT signaling pathway and increases the expression of inflammatory cytokines.

CONCLUSIONS: PVL is a significant S. aureus virulence factor, and upregulates the expression of proinflammatory cytokines but does not affect the expression of anti-inflammatory cytokines. The effect of PVL may be due to JAK/STAT pathway activation. Blockade of the JAK/STAT pathway may decrease the severity of PVL(+) MRSA pneumonia. PMID: 33017689 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33017689?dopt=Abstract

Source: Infection, Genetics and Evolution - October 1, 2020 Category: Genetics & Stem Cells Authors: Huang J, Zhang T, Zou X, Wu S, Zhu J Tags: Infect Genet Evol Source Type: research