Long non-coding RNA LINC00346 regulates proliferation and apoptosis by targeting miR-128-3p/SZRD1 axis in glioma.

CONCLUSIONS: LINC00346/miR-128-3p/SZRD1 axis played a crucial role in modulating the malignant progression of glioma, which may serve as a prognostic indicator and a probable therapeutic target for glioma. PMID: 33015801 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

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Conditions:   Brain Metastases;   Cancer;   Gliomas;   Glioblastoma Interventions:   Drug: F18 Fluciclovine;   Other: Standard of Care Sponsor:   M.D. Anderson Cancer Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Immunotherapy has changed the landscape of treatments for advanced disease in multiple neoplasms. More and more patients are long survivors from a metastatic disease. Most recently, the extension of indications and evidence of efficacy in early disease settings, such as the adjuvant and neoadjuvant setting in breast cancer, lung cancer, glioma, and gastric cancer, places more attention on what happens to patients who survive cancer. In particular, we evaluated what happens in young patients, a population in whom some immune-related effects are still poorly described. Immunotherapy is already a reality in early disease sett...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
u The behavior of lower-grade glioma (LGG) is changing over time, spontaneously, and in reaction to treatments. First, due to genomic instability and clonal expansion, although LGG progresses slowly during the early period of the disease, its growth velocity will accelerate when this tumor will transform to a higher grade of malignancy. Furthermore, its pattern of progression may change following therapy, e.g., by switching from a proliferative towards a more diffuse profile, in particular after surgical resection. In parallel to this plasticity of the neoplasm, the brain itself is constantly adapting to the tumor and ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
CONCLUSIONS: LY3200882 as monotherapy and combination therapy was safe and well tolerated with preliminary antitumor activity observed in PC. Further studies to evaluate the efficacy of LY3200882 with gemcitabine and nab-paclitaxel in advanced PC are warranted.PMID:34548321 | DOI:10.1158/1078-0432.CCR-21-1504
Source: Cell Research - Category: Cytology Authors: Source Type: research
Clin Cancer Res. 2021 Sep 21:clincanres.1412.2021. doi: 10.1158/1078-0432.CCR-21-1412. Online ahead of print.ABSTRACTPURPOSE: Immunotherapy is a promising approach for many oncological malignancies, including glioblastoma, however, there are currently no available tools or biomarkers to accurately assess whole-body immune responses in glioblastoma patients treated with immunotherapy. Here, the utility of OX40, a co-stimulatory molecule mainly expressed on activated effector T cells known to play an important role in eliminating cancer cells, was evaluated as a positron emission tomography (PET) imaging biomarker to quantif...
Source: Cell Research - Category: Cytology Authors: Source Type: research
CONCLUSIONS: LY3200882 as monotherapy and combination therapy was safe and well tolerated with preliminary antitumor activity observed in PC. Further studies to evaluate the efficacy of LY3200882 with gemcitabine and nab-paclitaxel in advanced PC are warranted.PMID:34548321 | DOI:10.1158/1078-0432.CCR-21-1504
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Source Type: research
Clin Cancer Res. 2021 Sep 21:clincanres.1412.2021. doi: 10.1158/1078-0432.CCR-21-1412. Online ahead of print.ABSTRACTPURPOSE: Immunotherapy is a promising approach for many oncological malignancies, including glioblastoma, however, there are currently no available tools or biomarkers to accurately assess whole-body immune responses in glioblastoma patients treated with immunotherapy. Here, the utility of OX40, a co-stimulatory molecule mainly expressed on activated effector T cells known to play an important role in eliminating cancer cells, was evaluated as a positron emission tomography (PET) imaging biomarker to quantif...
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Source Type: research
ConclusionsOur results indicate that PAK3 plays a unique role among PAKs in glioma development and may represent a potential therapeutic target.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research
Environ Int. 2021 Sep 18;158:106877. doi: 10.1016/j.envint.2021.106877. Online ahead of print.ABSTRACTHexavalent chromium [Cr(VI)] is a global environmental pollutant that increases risk for several types of cancers and is increasingly being recognized as a neurotoxicant. Traditionally, the brain has been viewed as a largely post-mitotic organ due to its specialized composition of neurons, and consequently, clastogenic effects were not considered in neurotoxicology. Today, we understand the brain is composed of at least eight distinct cell types - most of which continue mitotic activity throughout lifespan. We have learned...
Source: Environment International - Category: Environmental Health Authors: Source Type: research
Differences in the incidence and outcome of glioma between males and females are well known, being more striking for glioblastoma (GB) than low-grade glioma (LGG). The extensive and well-annotated data in publicly available databases enable us to analyze the molecular basis of these differences at a global level. Here, we have analyzed The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases to identify molecular indicators for these gender-based differences by different methods. Based on the nature of data available/accessible, the transcriptomic profile was studied in TCGA by using DeSeq2 and in CG...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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