Clinical evaluation of micro-fragmented adipose tissue as a treatment option for patients with meniscus tears with osteoarthritis: a prospective pilot study

AbstractPurposeThe management of knee pain secondary to meniscal tears with osteoarthritis is limited by the poor inherent healing potential of the meniscus. Previous studies have reported on the benefit of autologous micro-fragmented fat as a therapeutic for various knee pathologies. The goal of this prospective pilot study was to determine the safety and potential treatment effect of micro-fragmented adipose tissue injection for patients with knee pain secondary to osteoarthritis and meniscal tears who have failed conservative management.MethodsTwenty subjects with knee pain secondary to osteoarthritis with associated meniscal tear after failed conservative management were enrolled in the study. Numeric Pain Scale (NPS) and Knee Injury and Osteoarthritis Outcome Scale (KOOS) following ultrasound-guided intra-meniscal and intra-articular micro-fragmented adipose tissue injections were examined at three, six and 12 months.ResultsThe mean NPS revealed a significant decrease in patient pain at the 1-year time point compared with baseline (5.45 to 2.21,p
Source: International Orthopaedics - Category: Orthopaedics Source Type: research

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This paper reports the design of a high-accuracy spatial location estimation method using ultrasound waves by exploiting the fixed geometry of the transmitters. Assuming an isosceles triangle antenna configuration, where three antennas are placed as the vertices of an isosceles triangle, the spatial location problem can be formulated as a non-convex optimization problem whose interior is shown to admit a Riemannian manifold structure. Our investigation of the geometry of the newly introduced manifold (i.e., the manifold of all isosceles triangles in $mathbb {R}^3$) enables the design of highly efficient optimization algori...
Source: IEEE Transactions on Signal Processing - Category: Biomedical Engineering Source Type: research
This study develops a multi-spatiotemporal compounding CBE (MST-CBE) imaging approach for monitoring specific to CBUS thermal therapy. Methods: Ex vivo thermal ablations were performed with stereotactic positioning of a 180° directional CBUS applicator, temperature monitoring probes, endorectal US probe, and subsequent lesion sectioning and measurement. Five frames of raw radiofrequency data were acquired throughout in 15s intervals. Using window-by-window estimation methods, absolute and positive components of MST-CBE images at each point were obtained by the compounding ratio of squared envelope data within an increa...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion: We propose an experimental setup and deep learning based rupture detection for the complex OCT data in front of the needle tip, even in deeper tissue structures without the need for US or force sensor guiding. Significance: This study promises a suitable approach to complement a robust robotic needle placement.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion: The differential characteristics of EDA contributed highly to the accuracy of pain stimulation level detection of the classifiers. The external validity dataset was not considered in the study. Significance: Our approach has the potential for accurate pain quantification using EDA.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion: The performance of our three methods have proved that they can be potentially applied to other ultrasound-based medical imaging studies with unknown distributed positions of sensor array to enhance the imaging quality. Significance: The proposed methods can contribute to precise biomedical imaging with unknown distributed positions of sensor array in different application scenarios.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion: The developed DPLUS makes high-power ultrasound transmission in long and flexible thin waveguide possible. Significance: The concept of DPLUS for delivering high-power ultrasound is powerful in the field of Ultrasonics.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Source: Journal of Pain Research - Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
MR-guided focused ultrasound developer Insightec will be bringing its Exablat...Read more on AuntMinnie.comRelated Reading: CurveBeam, MedShape to collaborate on clinical study Insightec brings Exablate to Brazil Philips, InSightec to partner on MRgUS Insightec touts studies on focused ultrasound Lantheus, Insightec to partner
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
‚ÄčThe wrist is not commonly aspirated in the emergency department, but emergent arthrocentesis may be indicated for extreme or concerning cases, and tapping the wrist to determine the underlying pathology or relieve pain may be of great value. The synovial fluid from the joint space can be analyzed for crystals, infection, and blood. This information may help determine the overall plan and aid in decision-making and consultation. The ultimate treatment plan may include admission, intravenous antibiotics, multiple aspirations, and even surgical washout.A swollen, painful wrist that is hot to the touch is concerning for sep...
Source: The Procedural Pause - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
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