Rifampicin resistance patterns and dynamics of tuberculosis and drug-resistant tuberculosis in Enugu, South Eastern Nigeria

Conclusions: This first documentation of Rifampicin resistance patterns in MTB from Nigeria shows that a majority ofrpoB gene mutations occurred along codons 523 to 527, contrary to the widely reported codon 531 mutation and that multiple interventions such as combination therapy, with good compliance to treatment are needed to reduce both prevalence and development of TB drug resistance in the population.
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research