What Are the Seven Stages of Lewy Body Dementia?

Title: What Are the Seven Stages of Lewy Body Dementia?Category: Diseases and ConditionsCreated: 10/6/2020 12:00:00 AMLast Editorial Review: 10/6/2020 12:00:00 AM
Source: MedicineNet Alzheimer - Category: Geriatrics Source Type: news

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Blood vessels passing through the central nervous system are sheathed by specialized cells that form the blood-brain barrier. The barrier controls the passage of cells and molecules into the brain. This protection is essential to the normal function of the brain, which operates in a biological environment that is very different to that of the result of the body. Unfortunately, and like all systems in the body, the blood-brain barrier deteriorates with age. This allows harmful molecules and cells to leak into the brain, provoking a damaging state of chronic inflammation in brain tissue. Inflammation is thought to be an impo...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
In today's open access paper, researchers report a modest improvement in cerebral blood flow and cognitive performance in a small study of older individuals suffering cognitive impairment as a result of sustained hyperbaric oxygen treatment over a period of months. This seems a compensatory approach to therapy, in that improvements in cerebral blood flow should be expected to improve cognitive function at any age. This is the mechanism by which exercise rapidly improves memory function, for example. A direct comparison of hyperbaric oxygen treatment and exercise would be interesting. This result might help to inform...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
CONCLUSIONS: Misdiagnosis of younger patients with neurocognitive disorders is not uncommon, especially in cases of bvFTD. Late-onset psychiatric symptoms may be the harbinger to a neurodegenerative disease. Close follow-up and monitoring of these patients are necessary.PMID:34538074 | DOI:10.1176/appi.neuropsych.20100266
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Authors: Source Type: research
AbstractPurpose of ReviewBrain cholinergic denervation is a major feature of Alzheimer ’s disease (AD) and dementia with Lewy bodies (DLB). We reviewed the topography assessed by a cholinergic molecular imaging study in these two major types of dementia. A small meta-analysis directly comparing vesicular acetylcholine transporter (VAChT) PET scans of AD vs. DLB patients is presented .Recent FindingsVAChT PET studies showed evidence of extensive cortical cholinergic denervation in both forms of dementia, while multiple subcortical structures were also in DLB. Novel analysis revealed evidence of metathalamic denervatio...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
In conclusion, inhibiting the lysosomal oxidation of LDL in atherosclerotic lesions by antioxidants targeted at lysosomes causes the regression of atherosclerosis and improves liver and muscle characteristics in mice and might be a promising novel therapy for atherosclerosis in patients. NANOG Expression versus Cellular Senescence https://www.fightaging.org/archives/2021/09/nanog-expression-versus-cellular-senescence/ Are there many strategies that can reverse cellular senescence? There are certainly strategies that can lower levels of cellular senescence over time, both in cell cultures and in living an...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: This is the first study to document the demographic and clinical profile of Filipinos with MCI in a clinical setting. This review serves as a foundation for increased understanding of MCI with the ultimate goal of controlling the factors which may impact its prevention.PMID:34537768 | DOI:10.1159/000519171
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Authors: Source Type: research
Photo credit Sander Weeteling Dear Carol: My mom had younger-onset Alzheimer’s and my dad had Lewy body dementia, so I’ve spent years as a dementia caregiver. I don’t regret what I did for them, but I don’t want to put that worry on my own kids. I’m 60-years-old and try to live a healthy lifestyle, but every time I misstate an idea, forget a word, or neglect to do something routine, I wonder. Is this it? Is this the first sign? I can even see the concern in my kids’ faces when I do something a little off. I know that others with this genetic risk have the same fears. How do they handle t...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
The shrinkage is linked to developing Alzheimer's disease or another type of dementia.
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia Source Type: blogs
BACKGROUND AND PURPOSE: Persons with mild cognitive impairment (MCI) and Alzheimer dementia (AD) often experience gait and balance disturbances and depressive symptoms alongside their cognitive impairment. The aim of this study was to explore the relations...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Neurobiol Aging. 2021 Aug 21;108:72-79. doi: 10.1016/j.neurobiolaging.2021.08.011. Online ahead of print.ABSTRACTTauopathies are neurodegenerative diseases that are characterized by pathological accumulation of tau protein. Tau is hyperphosphorylated in the brain of tauopathy patients, and this phosphorylation is proposed to play a role in disease development. However, it has been unclear whether phosphorylation is different among different tauopathies. Here, we investigated the phosphorylation states of tau in several tauopathies, including corticobasal degeneration, Pick's disease, progressive supranuclear palsy (PSP), a...
Source: Neurobiology of Aging - Category: Geriatrics Authors: Source Type: research
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