Ultrasound Based Computational Fluid Dynamics Assessment of Brachial Artery Wall Shear Stress in Preeclamptic Pregnancy

AbstractPurposePreeclampsia (PE) is a pregnancy complication of abnormally elevated blood pressure and organ damage where endothelial function is impaired. Wall shear stress (WSS) strongly effects endothelial cell morphology and function but in PE the WSS values are unknown. WSS calculations from ultrasound inaccurately assume cylindrical arteries and patient specific computational fluid dynamics (CFD) typically require time-consuming 3D imaging such as CT or MRI.MethodsTwo-dimensional (2D) B-mode ultrasound images were lofted together to create simplified three-dimensional (3D) geometries of the brachial artery (BA) that incorporate artery curvature and non-circular cross sections. This process was efficient and on average took 120  ± 10 s. Patient specific CFD was then performed to quantify BA WSS for a small cohort of PE (n = 5) and normotensive pregnant patients (n = 5) and compared against WSS calculations assuming a cylindrical artery.ResultsFor several WSS metrics (time averaged WSS (TAWSS), peak systolic WSS, oscillatory shear index (OSI), OSI/TAWSS and relative residence time) CFD on the simplified arterial geometries calculated large spatial differences in WSS that assuming a cylindrical artery cannot calculate. Bland –Altman and intra-class correlation (ICC) analyses found assuming a cylindrical artery both underestimated (p 
Source: Cardiovascular Engineering and Technology - Category: Cardiology Source Type: research

Related Links:

Exp Ther Med. 2021 Oct;22(4):1066. doi: 10.3892/etm.2021.10500. Epub 2021 Jul 27.ABSTRACTDespite the significant evolution in recent years in the medical field, many fetal conditions that can be detected in the early stages, remain a social and economic burden due to a lack of diagnostic and treatment programs. The main objective of the present study was to realize a screening program related to the early detection of Down syndrome, by analyzing biochemical and imaging markers, in women from the rural areas of Southwest Romania. Accordingly, data from 269 pregnant women were taken into evaluation for maternal age, maternal...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research
AbstractAims/hypothesisWe aimed to identify potentially modifiable risk factors and causes for preterm delivery in women with type 1 or type 2 (pre-existing) diabetes.MethodsA secondary analysis of a prospective cohort study of 203 women with pre-existing diabetes (117 type 1 and 86 type 2 diabetes) was performed. Consecutive singleton pregnancies were included at the first antenatal visit between September 2015 and February 2018.ResultsIn total, 27% (n = 55) of the 203 women delivered preterm at median 36 + 0 weeks. When stratified by diabetes type, 33% of women with type 1 diabetes delive...
Source: Diabetologia - Category: Endocrinology Source Type: research
J Clin Endocrinol Metab. 2021 Aug 24:dgab617. doi: 10.1210/clinem/dgab617. Online ahead of print.ABSTRACTCONTEXT: Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across all three trimesters in women with antenatal complications.OBJECTIVE: To assess whether kisspeptin levels are altered in women with antenatal complications.DESIGN: Women with a...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Source Type: research
ConclusionsIncreased FPG in early pregnancy is closely related to fetal growth. Maternal characteristics may modify the associations between FPG and fetal adiposity in late pregnancy.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
by Nicolas Fragoso-Bargas, Julia O. Opsahl, Nadezhda Kiryushchenko, Yvonne B öttcher, Sindre Lee-Ødegård, Elisabeth Qvigstad, Kåre Rønn Richardsen, Christin W. Waage, Line Sletner, Anne Karen Jenum, Rashmi B. Prasad, Leif C. Groop, Gunn-Helen Moen, Kåre I. Birkeland, Christine Sommer Pregnancy is a valuable model to study the association between DNA methylation and several cardiometabolic traits, due to its direct potential to influence mother’s and child’s health. Epigenetics in Pregnancy (EPIPREG) is a population-based sample with the aim to study associations between DN ...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
AbstractStudy questionCould endometriosis-associated infertility be mitigated by metformin?Summary answerMetformin treatment restored fertility to control rates in endometriosis-induced mice that present lower fertility. No effect was observed on sham-operated mice.What is known alreadyEndometriosis is a gynaecological disorder characterized by ectopic vascularized endometrial tissue growth, mainly in pelvic cavity, which provokes pain and infertility. Corroborating observations in women, endometriosis decreases oocyte quality and pregnancy success in rodents, without affecting the number of ovulations, resorption rate and...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionCan antinuclear antibody (ANA) affect the subsequent live birth rate in patients with recurrent pregnancy loss (RPL) who have no antiphospholipid antibodies (aPLs)?Summary answerANA did not affect the pregnancy prognosis of RPL women.What is known alreadyThe prevalence of ANA is well-known to be higher in RPL patients. Our previous study found no difference in the live birth rates of ANA-positive and -negative patients who had no aPLs. Higher miscarriage rates were also reported in ANA-positive patients compared to ANA-negative patients with RPL. The RPL guidelines of the ESHRE state that “ANA t...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionCan antinuclear antibody (ANA) affect the subsequent live birth rate in patients with recurrent pregnancy loss (RPL) who have no antiphospholipid antibodies (aPLs)?Summary answerANA did not affect the pregnancy prognosis of RPL women.What is known alreadyThe prevalence of ANA is well-known to be higher in RPL patients. Our previous study found no difference in the live birth rates of ANA-positive and -negative patients who had no aPLs. Higher miscarriage rates were also reported in ANA-positive patients compared to ANA-negative patients with RPL. The RPL guidelines of the ESHRE state that “ANA t...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractStudy questionCan the adipokines levels and ratios in the follicular fluid (FF) be used to predict in vitro fertilization (IVF) outcomes?Summary answerThe leptin level and ratios leptin/ghrelin and leptin/adiponectin in FF are reliable prognostic factors for IVF outcomes in women with normal body mass index (BMI).What is known alreadyThe adipose tissue serves not a simple fat storage, rather an important endocrine organ, producing adipokines, such as leptin, adiponectin, ghrelin and others. Adipokines have been shown to regulate the cardiovascular system, food intake, metabolism, inflammation, metastatic spread of ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Due to metabolic changes in the second trimester and the increasing number of pregnant women with obesity and advanced maternal age, the incidence of gestational diabetes mellitus (GDM) remains high. This stud...
Source: Cardiovascular Ultrasound - Category: Radiology Authors: Tags: Research Source Type: research
More News: Cardiology | Cardiovascular | Diabetes | Endocrinology | Heart | Pregnancy | Ultrasound