Introduction

After the first description of amyloid infiltration in 1842 by Rokitansky, the chemical composition and pathogenesis of amyloid deposits became a matter of a heated dispute. Extensive evidence of a significant association between “primary” amyloidosis and myeloma-type proteins, particularly Bence Jones proteins, has been provided by the observations of my mentor, Elliott Osserman, in a seminal paper in 1964.1 The strongest evidence for the immunoglobulin origin of amyloid fibrils has come with the determination of the am ino acid sequence of 2 amyloid fibril proteins by George Glenner in 1971.
Source: Hematology/Oncology Clinics of North America - Category: Cancer & Oncology Authors: Source Type: research