Feasibility of 177Lu Therapy Monitoring Using Fast Whole-Body SPECT Recordings Provided by a High-Speed 360° CZT Camera

The whole-body absolute quantification of 177Lu-DOTATATE therapy was achieved using a high-speed 360° CZT SPECT/CT system. Twelve high-resolution swelling detectors may be positioned close to patients, providing a high-count sensitivity that is particularly advantageous for the low-count rate conditions of 177Lu imaging. After initially validating 177Lu quantification on phantom, serial whole-body SPECT/CT acquisitions of only 20 minutes were obtained for a 70-year-old woman treated by 177Lu-DOTATATE injections for a metastatic recurrence of a pancreatic neuroendocrine tumor. The progressive decrease in tumor uptake between the consecutive 177Lu-DOTATATE injections could be quantified, and thereby the corresponding dosimetry changes could be estimated.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Related Links:

Authors: Badenes Romero Á, Orozco Cortés J, Balaguer Muñoz D, Abreu Sánchez P, Mut Dólera T, Gómez Abril SÁ, Dolz Gaitón R, Caballero Calabuig E, Cueto Cañadas B, Latorre Agraz I, Reyes Ojeda MD, Plancha Mansanet C, Esteban Hurtado Á Abstract Neuroendocrine tumors (NET) are a heterogeneous group of neoplasms that originate in tissues derived from the neural crest, whose characteristic feature is the expression of neuroendocrine markers and somatostatin receptors. Here, we present the case of a patient with a surgically intervened small bowel NET....
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
AbstractObjectiveThe aim of this multicenter prospective study was to compare the sensitivity of18F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) with that of67Ga single photon emission computed tomography (SPECT) for the identification of the site of greatest importance for the final diagnosis of the cause of fever of unknown origin (FUO).MethodsThe study participants consisted of patients with an axillary temperature  ≥ 38.0 °C on ≥ 2 occasions within 1 week, with repeated episodes for ≥ 2 weeks prior to providing c...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
AbstractBackgroundData on the diagnostic and prognostic value of subtle abnormalities on myocardial perfusion imaging (MPI) are limited.Methods and resultsIn a retrospective single-center cohort of patients who underwent regadenoson SPECT-MPI, near-normal MPI was defined as normal left ventricular ejection fraction (LVEF  ≥ 50%) and a summed stress score (SSS) of 1-3 vs SSS = 0 in normal MPI. Borderline ischemia was defined as normal LVEF, SSS = 1-3, and a summed difference score (SDS) of 1 vs SDS = 0 in the absence of ischemia. Coronary angiography data within 6&n...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Authors: Johnson RD, Bath NK, Rinker J, Fong S, St James S, Pampaloni MH, Hope TA Abstract Coronary artery disease (CAD) is the leading cause of death in the United States (1). Myocardial perfusion imaging (MPI), using single photon emission computed tomography (SPECT) is one of the most frequently used diagnostic tools for patients at risk for CAD, and has significant prognostic value (2). Dedicated cardiac SPECT cameras such as the D-SPECT have been specifically designed for MPI studies. Equipped with new technology, the D-SPECT camera has demonstrated superior image quality when compared to standard SPECT or SPE...
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
Differentiated thyroid cancer has been treated with radioiodine for almost 80  years, although controversial questions regarding radiation-related risks and the optimisation of treatment regimens remain unresol...
Source: EJNMMI Physics - Category: Radiology Authors: Tags: Original research Source Type: research
ConclusionWhile patients with secondary ST/T abnormalities had significantly higher MACE risk, abnormal MPI or presence of myocardial ischemia on regadenoson SPECT-MPI in this group does not add prognostic information. Patients with primary ST abnormalities and T-wave abnormalities do not seem to have a significantly higher MACE risk compared to those with normal ECG; however, abnormal MPI or presence of myocardial ischemia, in these groups, correlates with higher MACE rates.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
ConclusionMental stress decreased the123I-mIBG HMR, increased mismatch between sympathetic activity and myocardial perfusion, and increased the heterogeneity of123I-mIBG uptake in ICM patients, while there was no significant change in myocardial defect size or the heterogeneity of99mTc-Tetrofosmin perfusion. The changes observed in this proof-of-concept study may provide valuable information about the trigger –substrate interaction and the potential vulnerability for ventricular arrhythmias.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
The objective of this study was to specify similarities and inconsistencies between these two biomarkers according to global characteristics of the disease. We conducted a retrospective study in 16 patients suffering from treatment-resistant MDD who underwent, during the same current episode, a cerebral perfusion SPECT with99mTc-HMPAO and a metabolic PET with18F-FDG. Whole-brain voxel-based SPM(T) maps were generated in correlation with the number of depressive episodes and in correlation with the depression duration, separately for the two exams (p-voxel    20).ResultsNo significant correlations were found b...
Source: EJNMMI Research - Category: Radiology Source Type: research
To better understand the pathophysiology of isolated head tremor, we investigated somatosensory temporal discrimination threshold (STDT) and dopaminergic neurotransmission with 123I-FP-CIT (DAT-SPECT) in patients with isolated head tremor, as well as potential correlations with their clinical features.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Short communication Source Type: research
Dopamine transporter SPECT with 123I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (123I-ioflupane) aids in the diagnosis of parkinsonian syndrome by demonstrating loss of striatal dopamine transporters, proportional to nigrostriatal dopaminergic neuronal loss. Quantitative software analysis (QSA) is a helpful adjunct to visual interpretation. An atlas of pearls and pitfalls of QSA is presented. Examples include correction for head tilt/orientation, scaling artifacts, and detection of balanced loss of activity. Additional examples are provided where QSA can potentially fail such as patient v...
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
More News: Brain | Mergers and Aquisitions | Neurology | Nuclear Medicine | Pancreas | SPECT