Clinical Evaluation of 18F-PI-2620 as a Potent PET Radiotracer Imaging Tau Protein in Alzheimer Disease and Other Neurodegenerative Diseases Compared With 18F-THK-5351

Conclusions 18F-PI-2620 PET might be a sensitive tool to detect cortical tau deposits in patients with Aβ+ AD and Aβ+ non-AD tauopathies. Furthermore, this study showed that “off-target” binding in the basal ganglia does not affect 18F-PI-2620.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Original Articles Source Type: research

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Authors: Cummings J Abstract Neuropsychiatric syndromes and symptoms play increasingly important roles in research diagnostic criteria for neurodegenerative disorders. Diagnostic criteria were reviewed including those for dementia, Alzheimer's disease, mild cognitive impairment, mild behavioral impairment, prodromal Alzheimer's disease, dementia with Lewy bodies, prodromal dementia with Lewy bodies, Parkinson's disease, multiple system atrophy, frontotemporal dementia, primary progressive aphasia, progressive supranuclear palsy, corticobasal degeneration, traumatic encephalopathy syndrome, Huntington' disease, amyo...
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
Conclusions: This study improves the knowledge on clinical significance of RBD symptoms in ET patients. Our preliminary findings demonstrate that presence of RBD in ET is associated with neurocognitive impairment, but not with cardiac autonomic dysfunction. Further longitudinal studies are needed to investigate whether ET patients with RBD will develop a frank dementia over the time. Introduction Essential tremor (ET) is one of the most common neurological disease among adults. Traditionally, it is defined by a core of clinical motor symptoms characterized by kinetic/postural tremor affecting hand, head, or other par...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Wei Li1†, Wei-Min Xiao1†, Yang-Kun Chen1*, Jian-Feng Qu1, Yong-Lin Liu1, Xue-Wen Fang2, Han-Yu Weng1 and Gen-Pei Luo11Department of Neurology, Dongguan People’s Hospital, Dongguan, China2Department of Radiology, Dongguan People’s Hospital, Dongguan, ChinaBackground: Anxiety is prevalent after a stroke. The pathophysiological mechanisms underlying the development of poststroke anxiety (PSA) remain unclear. The aim of this study was to investigate the clinical and neuroimaging risk factors for development of PSA and examine the effects of PSA on activities of daily living (ADL) and quality of life (...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
This article does not include any meta-analysis and aims simply at providing a comprehensive overview of the raw data reported in this field to date, as an aid to researchers.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Worldwide,  nearly44 million  people now have Alzheimer's disease (AD) or related dementia, making these conditions the  top cause of disabilities in later life. The biopharma industry has invested billions of dollars into research to treat and prevent AD1, yet this work has faced many obstacles, including difficulty identifying biomarkers, tracking the disease ’s progress in the brain, and recruiting patients to trials while they are still asymptomatic. But in recent years, we’ve begun to see breakthroughs that is driving our research in new directions. Many of these accomplishments were hi...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
CONCLUSION: LARS is reliable and valid for detecting and quantifying apathy in patients with dementia, even in very early stages of the disease. PMID: 26803583 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
CONCLUSION: These results revealed a widespread lack of familiarity with core diagnostic symptoms among non-specialists and suggest that community clinicians require specialized diagnostic support before providing a definitive diagnosis of bvFTD. PMID: 26741499 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Conclusion: These results revealed a widespread lack of familiarity with core diagnostic symptoms among non-specialists and suggest that community clinicians require specialized diagnostic support before providing a definitive diagnosis of bvFTD.Dement Geriatr Cogn Disord 2016;41:99-108
Source: Dementia and Geriatric Cognitive Disorders - Category: Geriatrics Source Type: research
Dr James Rowe, Consultant Neurologist BA (Cantab) BM BCh (Oxon) PhD (Lond) CCST FRCP (Lond) I lead regional specialist clinics for patients and carers with dementia, including frontotemporal dementia (also called Picks disease, Semantic dementia and Primary progressive aphasia), Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and the Cambridge Memory Clinic supporting people with mild cognitive impairment and Alzheimers disease. These clinics are supported by a dedicated team of doctors, nurses, psychologists and scientists, providing the very highest standards of care for pati...
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Tags: Cranial nerves, Dementia, Drugs: CNS (not psychiatric), Movement disorders (other than Parkinsons), Neuroimaging, Ophthalmology, Memory disorders (psychiatry), Psychiatry of old age PRESENTATION ABSTRACTS - DAY 2 Source Type: research
Professor John Hodges MD, FRCP, FRACP, F Med Sci John is Professor of Cognitive Neurology at the University of New South Wales based at the Neuroscience Research Australia where he co-directs the Frontotemporal Dementia Research Group (FRONTIER www.ftdrg.org). John qualified in Medicine from London University with honours (1975) and undertook periods of psychiatric and neurological raining in Southampton, Oxford and San Diego and obtained his MD in 1988. From 1997 to 2007 he was the MRC Professor of Behavioural Neurology with a joint appointments in the Department of Clinical Neuroscience at Addenbrooke's Hospital and the ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Tags: Dementia, Drugs: CNS (not psychiatric), Motor neurone disease, Neuroimaging, Neuromuscular disease, Parkinson's disease, Stroke, Memory disorders (psychiatry), Psychiatry of old age, Psychotic disorders (incl schizophrenia) PRESENTATION ABSTRACTS - DAY Source Type: research
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