Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life

ConclusionsCollectively, these data suggest that UPR/ER stress pathways are reduced in the cerebral cortex of agedChd8V986*/+ mice. Our study uncovers neurodevelopmental and age-related phenotypes inChd8V986*/+ mice and highlights the importance of controlling for age when studyingChd8 haploinsufficient mice.

http://link.springer.com/10.1186/s13229-020-00369-8

Source: Molecular Autism - October 4, 2020 Category: Molecular Biology Source Type: research