Molecules, Vol. 25, Pages 4568: Trypanocidal Essential Oils: A Review

Molecules, Vol. 25, Pages 4568: Trypanocidal Essential Oils: A Review Molecules doi: 10.3390/molecules25194568 Authors: Mayara Castro de Morais Jucieudo Virgulino de Souza Carlos da Silva Maia Bezerra Filho Silvio Santana Dolabella Damião Pergentino de Sousa Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis. There are few therapeutic options, and there is low efficacy to clinical treatment. Therefore, the search for new drugs for the trypanosomiasis is urgent. This review describes studies of the trypanocidal properties of essential oils, an important group of natural products widely found in several tropical countries. Seventy-seven plants were selected from literature for the trypanocidal activity of their essential oils. The main chemical constituents and mechanisms of action are also discussed. In vitro and in vivo experimental data show the therapeutic potential of these natural products for the treatment of infections caused by species of Trypanosoma.
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research