IJERPH, Vol. 17, Pages 7287: Effects of Inhaled Corticosteroids and Particle Size on Risk of Obstructive Sleep Apnea: A Large Retrospective Cohort Study

Conclusions: Use of ICS appears to be an independent risk factor for OSA. Notably, extra-fine particle size ICS do not appear to be associated with an increased risk of OSA.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research

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Abstract Obstructive sleep apnea (OSA) and asthma are highly prevalent chronic respiratory disorders. Beyond frequent coexistence arising from their high prevalence and shared risk factors, these disorders feature a reciprocal interaction, whereby each disease impacts the severity of the other. Emerging evidence implicates airway and systemic inflammation, neuroimmune interactions, as well as effects of asthma-controlling medications (corticosteroids) as factors predisposing patients with asthma to OSA. Conversely, undiagnosed or inadequately treated OSA adversely affects asthma control, partly via effects of inte...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Introduction: Comorbidities and poor adherence are common features in patients with difficult-to-control asthma. However, the relative effect of these parameters on asthma control and exacerbations is less investigated.Aim: To examine the impact of comorbidities, poor inhaler technique and adherence on asthma control and frequent exacerbations in a representative cohort of patients with difficult-to-control asthma.Methods: All adult asthma patients (n=1034) seen in four respiratory clinics over one year were screened prospectively for asthma severity. Patients with difficult-to-control asthma according to ERS/ATS criteria ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Poor control in patients with difficult-to-treat asthma might be due to several factors, including poor adherence and undertreated asthma co-morbidities. After an assessment addressing these issues, only few patients still need targeted therapy.We aimed to evaluate the effect of a multidimensional intervention in improvement asthma control in patients with difficult asthma.Fifty patients with difficult asthma were prospectively included in this study conducted in AbderrahmenMami hospital between March 2018 and September 2018. Clinical, biological and functional characteristics were collected. Then, coexisting conditions (p...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway pharmacology and treatment Source Type: research
The objective of this abstract is to evaluate preliminary clinical outcomes of the integrated SCD-pulmonary clinic during the intervention phase (July 2017-June 2018) compared to 24 months prior to implementation (July 2015-June 2017). We hypothesized an integrated clinic model would improve access to specialized pulmonary care for children with SCD and reduce hospitalizations for vaso-occlusive episodes (VOEs). The primary endpoints are adherence to pulmonary clinic appointments and unplanned acute healthcare utilization for SCD-related complications and/or asthma exacerbations. Secondary endpoints are the number of unpla...
Source: Blood - Category: Hematology Authors: Tags: 901. Health Services Research-Non-Malignant Conditions: Poster III Source Type: research
Background: Unrecognized obstructive sleep apnea syndrome (OSAS) may lead to poor asthma control despite optimal therapy. We aimed to assess the prevalence of OSAS among patients with nocturnal symptoms and poorly controlled asthma.Methods: Patients with nocturnal asthma symptoms despite receiving at least moderate dose of inhaled corticosteroid and long acting bronchodilators underwent a limited sleep study using "Embletta" portable diagnostic system (Medcare, Iceland).Results: [mean (SD) unless stated otherwise]: Among 145 patients recruited, 122 patients underwent sleep study with 62 subjects (50.8%) had AHI &...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and Control of Breathing Source Type: research
Conclusions: CPAP therapy for 3 months in OSAS patients with nocturnal asthma despite treatment with at least moderate dose inhaled corticosteroid and long acting bronchodilators did not improve asthma control but alleviated daytime sleepiness and improved asthma related quality of life.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and Control of Breathing Source Type: research
ConclusionsPatients with CRS often present with uncontrolled asthma, and ESS improves both miniAQLQ and ACT. Approximately half of patients with uncontrolled asthma improve after ESS, yet there are few CRS‐specific factors associated with asthma QOL or control or ESS outcomes.This article is protected by copyright. All rights reserved.
Source: Allergy - Category: Allergy & Immunology Authors: Tags: Original Article: Airway Diseases Source Type: research
This article briefly overviews the epidemiology, unique distinguishing features, potential mechanisms, and approach to management of patients with obesity-related asthma in adults. PMID: 27336439 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
This article describes a case involving a 52-year-old woman with idiopathic scoliosis who was referred to the authors? centre for an unresolving pneumonia. Implementation of a targeted screening program to detect airflow obstruction suggestive of chronic obstructive pulmonary disease within a presurgical screening clinicChronic obstructive pulmonary disease (COPD) affects a significant proportion of the population =40 years of age, and is a leading cause of hospitalization, emergency department visits and mortality. Unfortunately, however, COPD appears to be underdiagnosed and is poorly controlled in many individuals. Ther...
Source: Canadian Respiratory Journal - Category: Respiratory Medicine Source Type: research
This study investigated the impact of a relatively inexpensive tool aimed to improve patient care and outcomes at a quaternary care academic hospital in Toronto, Ontario. Bronchiectasis exacerbations: The role of atypical bacteria, respiratory syncytial virus and pulmonary function testsA significant proportion of bronchiectasis exacerbations may be explained by chronic colonization of the lower respiratory tract by Haemophilus influenzae and Pseudomonas species. Less studied, however, is the involvement of viruses and atypical bacteria. Using polymerase chain reaction in bronchoalveolar lavage samples, this observational,...
Source: Canadian Respiratory Journal - Category: Respiratory Medicine Source Type: research
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